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    Kit KIT proto-oncogene receptor tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 16590, updated on 14-Sep-2021

    Summary

    Official Symbol
    Kitprovided by MGI
    Official Full Name
    KIT proto-oncogene receptor tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:96677
    See related
    Ensembl:ENSMUSG00000005672
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    W; Bs; SC; SO; Fdc; Ssm; Gsfs; SCO1; SCO5; SOW3; Tr-k; c-KI; CD117; belly; c-KIT; Tr-kit; Gsfsco1; Gsfsco5; Gsfsow3
    Summary
    The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lung adult (RPKM 39.0), cerebellum adult (RPKM 19.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kit in Genome Data Viewer
    Location:
    5 C3.3; 5 39.55 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (75735647..75817382)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (75574987..75656722)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (75971012..76052747)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sterol O-acyltransferase 1 pseudogene Neighboring gene predicted gene, 24502 Neighboring gene predicted gene, 32558 Neighboring gene predicted gene, 54290

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cytokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables stem cell factor receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in B cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Fc receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Kit signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Kit signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to thyroid hormone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of mechanical stimulus involved in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within developmental pigmentation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within developmental pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ectopic germ cell programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_negative_effect erythrocyte differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in erythropoietin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within germ cell development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in germ cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glycosphingolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hematopoietic progenitor cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within hematopoietic stem cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immature B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lamellipodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within lymphoid progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mast cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mast cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in megakaryocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in melanocyte adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in melanocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in melanocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within myeloid leukocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within myeloid progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within pigmentation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MAP kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of colon smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mast cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of pyloric antrum smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of small intestine smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein autophosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in somatic stem cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    mast/stem cell growth factor receptor Kit
    Names
    Dominant white spotting
    SCFR
    Steel Factor Receptor
    belly-spot
    c-kit proto-oncogene protein
    dominant spotting
    kit oncogene
    proto-oncogene c-Kit
    proto-oncogene tyrosine-protein kinase Kit
    spotted sterile male
    tyrosine-protein kinase Kit
    NP_001116205.1
    NP_066922.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122733.1NP_001116205.1  mast/stem cell growth factor receptor Kit isoform 1 precursor

      See identical proteins and their annotated locations for NP_001116205.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK047010, BC052457, BY123520
      Consensus CDS
      CCDS51525.1
      UniProtKB/Swiss-Prot
      P05532
      Related
      ENSMUSP00000005815.7, ENSMUST00000005815.7
      Conserved Domains (6) summary
      cd05860
      Location:314414
      Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
      smart00410
      Location:221310
      IG_like; Immunoglobulin like
      cd05104
      Location:556930
      PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
      pfam00047
      Location:217308
      ig; Immunoglobulin domain
      pfam07714
      Location:592926
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:427501
      Ig; Immunoglobulin domain
    2. NM_021099.3NP_066922.2  mast/stem cell growth factor receptor Kit isoform 2 precursor

      See identical proteins and their annotated locations for NP_066922.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the CDS and encodes a shorter isoform, as compared to variant 1.
      Source sequence(s)
      AY536430, BC052457, BY017579
      Consensus CDS
      CCDS80302.1
      UniProtKB/Swiss-Prot
      P05532
      Related
      ENSMUSP00000116465.3, ENSMUST00000144270.8
      Conserved Domains (6) summary
      cd05860
      Location:314414
      Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
      smart00410
      Location:221310
      IG_like; Immunoglobulin like
      cd05104
      Location:552926
      PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
      pfam00047
      Location:217308
      ig; Immunoglobulin domain
      pfam07714
      Location:588922
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:427501
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      75735647..75817382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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