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    Kif5c kinesin family member 5C [ Mus musculus (house mouse) ]

    Gene ID: 16574, updated on 22-Aug-2021

    Summary

    Official Symbol
    Kif5cprovided by MGI
    Official Full Name
    kinesin family member 5Cprovided by MGI
    Primary source
    MGI:MGI:1098269
    See related
    Ensembl:ENSMUSG00000026764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Khc; KINN; NKHC; NKHC2
    Expression
    Biased expression in cortex adult (RPKM 81.9), cerebellum adult (RPKM 60.5) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kif5c in Genome Data Viewer
    Location:
    2 C1.1; 2 28.68 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (49509298..49664790)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (49619286..49774778)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (49474834..49630298)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25215 Neighboring gene enhancer of polycomb homolog 2 Neighboring gene predicted gene, 46738 Neighboring gene LY6/PLAUR domain containing 6B Neighboring gene LY6/PLAUR domain containing 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables apolipoprotein receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule motor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in distal axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of kinesin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of kinesin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    kinesin heavy chain isoform 5C
    Names
    kinesin heavy chain member 5C
    kinesin heavy chain neuron-specific 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008449.3NP_032475.2  kinesin heavy chain isoform 5C

      See identical proteins and their annotated locations for NP_032475.2

      Status: VALIDATED

      Source sequence(s)
      BC067051, CJ113909
      Consensus CDS
      CCDS16024.1
      UniProtKB/Swiss-Prot
      P28738
      Related
      ENSMUSP00000028102.8, ENSMUST00000028102.14
      Conserved Domains (4) summary
      smart00129
      Location:8334
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01369
      Location:6327
      KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup
      pfam15619
      Location:605798
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cl12013
      Location:636817
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      49509298..49664790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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