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    Kif5b kinesin family member 5B [ Mus musculus (house mouse) ]

    Gene ID: 16573, updated on 8-Jul-2021

    Summary

    Official Symbol
    Kif5bprovided by MGI
    Official Full Name
    kinesin family member 5Bprovided by MGI
    Primary source
    MGI:MGI:1098268
    See related
    Ensembl:ENSMUSG00000006740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Khc; Khcs; Kns1; Ukhc; AL022807
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 26.1), bladder adult (RPKM 26.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kif5b in Genome Data Viewer
    Location:
    18 A1; 18 4.46 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (6201005..6241524, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (6201005..6241524, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (6201003..6241522, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 12 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene predicted gene, 18278 Neighboring gene predicted gene, 41664 Neighboring gene ribosomal protein L27, pseudogene 3 Neighboring gene prothymosin alpha pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables JUN kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule lateral binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule motor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anterograde dendritic transport of neurotransmitter receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in centrosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cytoplasm organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within microtubule-based process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrial transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within plus-end-directed vesicle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission, GABAergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of voltage-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde neuronal dense core vesicle transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress granule disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within vesicle transport along microtubule IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in vesicle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of kinesin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinesin-1 heavy chain
    Names
    conventional kinesin heavy chain
    kinesin heavy chain member 5B, ubiquitous
    ubiquitous kinesin heavy chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008448.3NP_032474.2  kinesin-1 heavy chain

      See identical proteins and their annotated locations for NP_032474.2

      Status: VALIDATED

      Source sequence(s)
      AC113003, AI788274, AK014590, AV316286, BC090841
      Consensus CDS
      CCDS37724.1
      UniProtKB/Swiss-Prot
      Q61768
      UniProtKB/TrEMBL
      Q9CUT6
      Related
      ENSMUSP00000025083.8, ENSMUST00000025083.14
      Conserved Domains (5) summary
      smart00129
      Location:8332
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01369
      Location:6325
      KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup
      pfam05010
      Location:467662
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam07851
      Location:598686
      TMPIT; TMPIT-like protein
      pfam14235
      Location:462538
      DUF4337; Domain of unknown function (DUF4337)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      6201005..6241524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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