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    Kif3b kinesin family member 3B [ Mus musculus (house mouse) ]

    Gene ID: 16569, updated on 2-Nov-2024

    Summary

    Official Symbol
    Kif3bprovided by MGI
    Official Full Name
    kinesin family member 3Bprovided by MGI
    Primary source
    MGI:MGI:107688
    See related
    Ensembl:ENSMUSG00000027475 AllianceGenome:MGI:107688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0359
    Summary
    Enables intraciliary transport particle B binding activity. Involved in anterograde dendritic transport of neurotransmitter receptor complex; cilium assembly; and vesicle-mediated transport. Located in centrosome; cilium; and dendrite. Part of kinesin II complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; nervous system; and nose. Used to study schizophrenia. Human ortholog(s) of this gene implicated in retinitis pigmentosa 89. Orthologous to human KIF3B (kinesin family member 3B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 23.3), CNS E18 (RPKM 14.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kif3b in Genome Data Viewer
    Location:
    2 H1; 2 75.41 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (153132028..153175310)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153291395..153333390)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene pleiomorphic adenoma gene-like 2 Neighboring gene protein O-fucosyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7868 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:153088886-153089039 Neighboring gene STARR-positive B cell enhancer ABC_E6002 Neighboring gene predicted gene, 39961 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:153161910-153162194 Neighboring gene RIKEN cDNA 2500004C02 gene Neighboring gene STARR-positive B cell enhancer ABC_E7869 Neighboring gene STARR-seq mESC enhancer starr_06089 Neighboring gene STARR-positive B cell enhancer ABC_E7870 Neighboring gene ASXL transcriptional regulator 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables intraciliary transport particle B binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in anterograde dendritic transport of neurotransmitter receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in anterograde dendritic transport of neurotransmitter receptor complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intraciliary transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intraciliary transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in opsin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in opsin transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of kinesin II complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of kinesin II complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    kinesin-like protein KIF3B
    Names
    microtubule plus end-directed kinesin motor 3B
    NP_032470.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008444.4NP_032470.3  kinesin-like protein KIF3B

      See identical proteins and their annotated locations for NP_032470.3

      Status: VALIDATED

      Source sequence(s)
      AK147467, BC065132, CJ089315
      Consensus CDS
      CCDS16911.1
      UniProtKB/Swiss-Prot
      Q3UFZ8, Q61771, Q8BNH4
      UniProtKB/TrEMBL
      Q3UHC4, Q80U27
      Related
      ENSMUSP00000028977.7, ENSMUST00000028977.7
      Conserved Domains (2) summary
      cd01371
      Location:8340
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
      pfam00225
      Location:15340
      Kinesin; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      153132028..153175310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_374419.4 RNA Sequence