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    Kif2a kinesin family member 2A [ Mus musculus (house mouse) ]

    Gene ID: 16563, updated on 9-Aug-2021

    Summary

    Official Symbol
    Kif2aprovided by MGI
    Official Full Name
    kinesin family member 2Aprovided by MGI
    Primary source
    MGI:MGI:108390
    See related
    Ensembl:ENSMUSG00000021693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kn; Kif; Kif2; Kns2; M-ki; M-kinesin; C530030B14Rik
    Expression
    Broad expression in CNS E18 (RPKM 12.1), frontal lobe adult (RPKM 11.5) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kif2a in Genome Data Viewer
    Location:
    13; 13 D2.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (107095504..107158931, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (106958996..107022355, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (107750665..107812194, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Ipo11-lrrc70 readthrough Neighboring gene importin 11 Neighboring gene leucine rich repeat containing 70 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) Neighboring gene RIKEN cDNA 3830408C21 gene Neighboring gene predicted gene, 31715

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of centriolar subdistal appendage ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF2A
    Names
    kinesin heavy chain member 2
    kinesin-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145779.1NP_001139251.1  kinesin-like protein KIF2A isoform 2

      See identical proteins and their annotated locations for NP_001139251.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and in the 3' coding region, compared to variant 1. An upstream start codon with a strong Kozak signal is used by this variant. The predicted protein (isoform 2) has a longer and distinct N-terminus and a shorter C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC154257, AC154328, AK016720, AK037037, CF581603
      Consensus CDS
      CCDS49356.1
      UniProtKB/Swiss-Prot
      P28740
      UniProtKB/TrEMBL
      Q9D481
      Related
      ENSMUSP00000022204.10, ENSMUST00000022204.16
      Conserved Domains (1) summary
      cd01367
      Location:222550
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    2. NM_001374727.1NP_001361656.1  kinesin-like protein KIF2A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154257, AC154328
      Consensus CDS
      CCDS88521.1
      Related
      ENSMUSP00000125644.2, ENSMUST00000159772.8
      Conserved Domains (1) summary
      cd01367
      Location:222550
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    3. NM_001378936.1NP_001365865.1  kinesin-like protein KIF2A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154257, AC154328
      Related
      ENSMUSP00000113921.3, ENSMUST00000117423.9
      Conserved Domains (1) summary
      cd01367
      Location:176504
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    4. NM_001378937.1NP_001365866.1  kinesin-like protein KIF2A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154257, AC154328
      Conserved Domains (1) summary
      cd01367
      Location:203531
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    5. NM_001378938.1NP_001365867.1  kinesin-like protein KIF2A isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154257, AC154328
      Conserved Domains (1) summary
      cd01367
      Location:203531
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    6. NM_001378939.1NP_001365868.1  kinesin-like protein KIF2A isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC154257, AC154328
      Conserved Domains (1) summary
      cd01367
      Location:195523
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    7. NM_001378940.1NP_001365869.1  kinesin-like protein KIF2A isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC154257, AC154328
      Related
      ENSMUSP00000113361.2, ENSMUST00000117539.8
      Conserved Domains (1) summary
      cd01367
      Location:203531
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    8. NM_008442.2NP_032468.2  kinesin-like protein KIF2A isoform 1

      See identical proteins and their annotated locations for NP_032468.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC154257, AC154328, AK016720, AK037037, BB622253, BE863830, CF581603
      Consensus CDS
      CCDS26759.1
      UniProtKB/TrEMBL
      Q9D481
      Related
      ENSMUSP00000112715.2, ENSMUST00000122233.8
      Conserved Domains (2) summary
      smart00129
      Location:195531
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01367
      Location:195523
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      107095504..107158931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157877.1XP_036013770.1  kinesin-like protein KIF2A isoform X1

      Conserved Domains (1) summary
      cd01367
      Location:176504
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    2. XM_036157878.1XP_036013771.1  kinesin-like protein KIF2A isoform X2

      Conserved Domains (1) summary
      cd01367
      Location:222536
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group

    RNA

    1. XR_004937942.1 RNA Sequence

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