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    Kif1b kinesin family member 1B [ Mus musculus (house mouse) ]

    Gene ID: 16561, updated on 31-Jan-2019

    Summary

    Official Symbol
    Kif1bprovided by MGI
    Official Full Name
    kinesin family member 1Bprovided by MGI
    Primary source
    MGI:MGI:108426
    See related
    Ensembl:ENSMUSG00000063077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D4Mil1e; AI448212; AI506502; KIF1Bp130; KIF1Bp204; A530096N05Rik
    Expression
    Broad expression in cerebellum adult (RPKM 37.2), cortex adult (RPKM 32.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See Kif1b in Genome Data Viewer
    Location:
    4 E2; 4 79.05 cM
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (149176319..149307733, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (148550430..148681807, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA, pseudogene 12 Neighboring gene phosphogluconate dehydrogenase Neighboring gene ubiquitination factor E4B, opposite strand 3 Neighboring gene ubiquitination factor E4B Neighboring gene tRNA methyltransferase 11-2, pseudogene 2 Neighboring gene retinol binding protein 7, cellular

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0591

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATP-dependent microtubule motor activity, plus-end-directed IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule binding TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    anterograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterograde neuronal dense core vesicle transport ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton-dependent intracellular transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryo development ending in birth or egg hatching NAS
    Non-traceable Author Statement
    more info
    PubMed 
    lysosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion transport along microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron-neuron synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    retrograde neuronal dense core vesicle transport ISO
    Inferred from Sequence Orthology
    more info
     
    transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion HDA PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF1B
    Names
    N-3 kinesin
    kinesin heavy chain member 1B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290995.1NP_001277924.1  kinesin-like protein KIF1B isoform c

      See identical proteins and their annotated locations for NP_001277924.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AF131865, AI848477, AK134946, BC059901, BE952257, CF746574, CJ104954
      Consensus CDS
      CCDS71521.1
      UniProtKB/Swiss-Prot
      Q60575
      UniProtKB/TrEMBL
      Q3UY61, Q6PB45
      Related
      ENSMUSP00000056754.6, ENSMUST00000060537.12
      Conserved Domains (9) summary
      smart00129
      Location:5361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:532636
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:17011799
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:17021795
      PH; PH domain
      pfam12423
      Location:845892
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:13131413
      DUF3694; Kinesin protein
      pfam16183
      Location:358555
      Kinesin_assoc; Kinesin-associated
      cl09111
      Location:662717
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    2. NM_008441.2NP_032467.2  kinesin-like protein KIF1B isoform a

      See identical proteins and their annotated locations for NP_032467.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains multiple coding region differences, including an alternate 3' terminal exon, compared to variant 3. It encodes isoform a, which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AK134946, AL731655, CJ130277, D17577
      Consensus CDS
      CCDS18957.1
      UniProtKB/Swiss-Prot
      Q60575
      UniProtKB/TrEMBL
      A2AH75, Q3UY61
      Related
      ENSMUSP00000030806.5, ENSMUST00000030806.5
      Conserved Domains (4) summary
      smart00129
      Location:5355
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:486590
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:352509
      Kinesin_assoc; Kinesin-associated
    3. NM_207682.2NP_997565.2  kinesin-like protein KIF1B isoform b

      See identical proteins and their annotated locations for NP_997565.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains multiple coding region differences, compared to variant 3. The resulting isoform (b) is shorter than isoform c.
      Source sequence(s)
      AK041278, AK134946, AK147409, BC059901, CJ130277
      Consensus CDS
      CCDS18956.1
      UniProtKB/TrEMBL
      Q3UY61, Q6PB45
      Related
      ENSMUSP00000061472.8, ENSMUST00000055647.14
      Conserved Domains (9) summary
      smart00129
      Location:5355
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:486590
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16551753
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:16561749
      PH; PH domain
      pfam12423
      Location:799846
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12671367
      DUF3694; Kinesin protein
      pfam16183
      Location:352509
      Kinesin_assoc; Kinesin-associated
      cl09111
      Location:616671
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      149176319..149307733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538595.3XP_006538658.1  kinesin-like protein KIF1B isoform X6

      See identical proteins and their annotated locations for XP_006538658.1

      Conserved Domains (9) summary
      smart00129
      Location:5361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15781676
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:15791672
      PH; PH domain
      pfam12423
      Location:805851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11901290
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
      cl09111
      Location:622677
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    2. XM_006538593.3XP_006538656.1  kinesin-like protein KIF1B isoform X4

      See identical proteins and their annotated locations for XP_006538656.1

      Conserved Domains (9) summary
      smart00129
      Location:5361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16611759
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:16621755
      PH; PH domain
      pfam12423
      Location:805852
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12731373
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
      cl09111
      Location:622677
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    3. XM_006538591.3XP_006538654.1  kinesin-like protein KIF1B isoform X2

      See identical proteins and their annotated locations for XP_006538654.1

      Conserved Domains (9) summary
      smart00129
      Location:5361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:518622
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16871785
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:16881781
      PH; PH domain
      pfam12423
      Location:831878
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12991399
      DUF3694; Kinesin protein
      pfam16183
      Location:358541
      Kinesin_assoc; Kinesin-associated
      cl09111
      Location:648703
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    4. XM_006538592.3XP_006538655.1  kinesin-like protein KIF1B isoform X3

      See identical proteins and their annotated locations for XP_006538655.1

      Conserved Domains (9) summary
      smart00129
      Location:5361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:506610
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16751773
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:16761769
      PH; PH domain
      pfam12423
      Location:819866
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12871387
      DUF3694; Kinesin protein
      pfam16183
      Location:358529
      Kinesin_assoc; Kinesin-associated
      cl09111
      Location:636691
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    5. XM_006538594.3XP_006538657.1  kinesin-like protein KIF1B isoform X5

      See identical proteins and their annotated locations for XP_006538657.1

      Conserved Domains (9) summary
      smart00129
      Location:5361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:532636
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16181716
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:16191712
      PH; PH domain
      pfam12423
      Location:845891
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12301330
      DUF3694; Kinesin protein
      pfam16183
      Location:358555
      Kinesin_assoc; Kinesin-associated
      cl09111
      Location:662717
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    6. XM_006538590.3XP_006538653.1  kinesin-like protein KIF1B isoform X1

      See identical proteins and their annotated locations for XP_006538653.1

      Conserved Domains (9) summary
      smart00129
      Location:5355
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:526630
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16951793
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:16961789
      PH; PH domain
      pfam12423
      Location:839886
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:13071407
      DUF3694; Kinesin protein
      pfam16183
      Location:352549
      Kinesin_assoc; Kinesin-associated
      cl09111
      Location:656711
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    7. XM_011250200.2XP_011248502.1  kinesin-like protein KIF1B isoform X7

      See identical proteins and their annotated locations for XP_011248502.1

      Conserved Domains (6) summary
      smart00129
      Location:5361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:532636
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:845892
      KIF1B; Kinesin protein 1B
      pfam16183
      Location:358555
      Kinesin_assoc; Kinesin-associated
      cl09111
      Location:662717
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    8. XM_006538596.3XP_006538659.1  kinesin-like protein KIF1B isoform X8

      See identical proteins and their annotated locations for XP_006538659.1

      Conserved Domains (4) summary
      smart00129
      Location:5361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:532636
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:358555
      Kinesin_assoc; Kinesin-associated

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_166299.2 Reference GRCm38.p4 NOD/MrkTac

      Range
      2596702..2728204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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