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    DQX1 DEAQ-box RNA dependent ATPase 1 [ Homo sapiens (human) ]

    Gene ID: 165545, updated on 5-Mar-2024

    Summary

    Official Symbol
    DQX1provided by HGNC
    Official Full Name
    DEAQ-box RNA dependent ATPase 1provided by HGNC
    Primary source
    HGNC:HGNC:20410
    See related
    Ensembl:ENSG00000144045 MIM:620580; AllianceGenome:HGNC:20410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in DNA duplex unwinding. Predicted to be part of spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum (RPKM 13.5), small intestine (RPKM 12.8) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DQX1 in Genome Data Viewer
    Location:
    2p13.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (74518131..74526231, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (74526696..74534796, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74745258..74753358, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene LBX2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74734085-74735015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16069 Neighboring gene polycomb group ring finger 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74739895-74740563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74742813-74743314 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74743315-74743814 Neighboring gene T cell leukemia homeobox 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74756279-74757161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16073 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16075 Neighboring gene AUP1 lipid droplet regulating VLDL assembly factor Neighboring gene HtrA serine peptidase 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:74763605-74764106 Neighboring gene lysyl oxidase like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11669 Neighboring gene Sharpr-MPRA regulatory regions 4995 and 13004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74781947-74782464 Neighboring gene docking protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23757

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DQX1
    Names
    DEAQ RNA-dependent ATPase DQX1
    DEAQ box polypeptide 1 (RNA-dependent ATPase)
    NP_598376.2
    XP_011530947.1
    XP_047299539.1
    XP_047299540.1
    XP_054196855.1
    XP_054196856.1
    XP_054196857.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133637.3NP_598376.2  ATP-dependent RNA helicase DQX1

      See identical proteins and their annotated locations for NP_598376.2

      Status: VALIDATED

      Source sequence(s)
      AA515987, BC033238, BC075018, BM987933, DA852016
      Consensus CDS
      CCDS1949.2
      UniProtKB/Swiss-Prot
      Q6B017, Q8NAM8, Q8TE96
      Related
      ENSP00000384621.3, ENST00000404568.4
      Conserved Domains (5) summary
      smart00487
      Location:41231
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:465530
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:65204
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cl22853
      Location:889
      Motor_domain; Myosin and Kinesin motor domain
      pfam07717
      Location:565674
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      74518131..74526231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443583.1XP_047299539.1  ATP-dependent RNA helicase DQX1 isoform X1

    2. XM_011532645.1XP_011530947.1  ATP-dependent RNA helicase DQX1 isoform X2

      Conserved Domains (2) summary
      smart00847
      Location:223288
      HA2; Helicase associated domain (HA2) Add an annotation
      pfam07717
      Location:323432
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    3. XM_047443584.1XP_047299540.1  ATP-dependent RNA helicase DQX1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      74526696..74534796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340880.1XP_054196855.1  ATP-dependent RNA helicase DQX1 isoform X1

    2. XM_054340881.1XP_054196856.1  ATP-dependent RNA helicase DQX1 isoform X2

    3. XM_054340882.1XP_054196857.1  ATP-dependent RNA helicase DQX1 isoform X3