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    Jak2 Janus kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 16452, updated on 8-Jul-2024

    Summary

    Official Symbol
    Jak2provided by MGI
    Official Full Name
    Janus kinase 2provided by MGI
    Primary source
    MGI:MGI:96629
    See related
    Ensembl:ENSMUSG00000024789 AllianceGenome:MGI:96629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fd17
    Summary
    Enables interleukin-12 receptor binding activity and protein tyrosine kinase activity. Involved in several processes, including hemopoiesis; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to lipid; and regulation of apoptotic process. Located in caveola and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and musculoskeletal system. Used to study essential thrombocythemia; myelofibrosis; myeloproliferative neoplasm; and polycythemia vera. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 6.6), CNS E18 (RPKM 6.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Jak2 in Genome Data Viewer
    Location:
    19 C1; 19 23.73 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (29229006..29290495)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (29251803..29313095)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RNA terminal phosphate cyclase-like 1 Neighboring gene STARR-seq mESC enhancer starr_45880 Neighboring gene microRNA 101b Neighboring gene predicted gene 5518 Neighboring gene STARR-seq mESC enhancer starr_45881 Neighboring gene STARR-positive B cell enhancer ABC_E11673 Neighboring gene predicted gene, 41829 Neighboring gene STARR-seq mESC enhancer starr_45882 Neighboring gene STARR-seq mESC enhancer starr_45883 Neighboring gene insulin-like 6 Neighboring gene relaxin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3Y41 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin receptor substrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-12 receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables type 1 angiotensin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of Janus kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to dexamethasone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to interleukin-3 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in collagen-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytokine-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in erythrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in granulocyte-macrophage colony-stimulating factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in growth hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in growth hormone receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hormone-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-12-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-3-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-5-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mammary gland epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microglial cell activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear receptor-mediated mineralocorticoid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MHC class II biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of NK T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NK T cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T-helper 17 type immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of growth factor dependent skeletal muscle satellite cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of growth hormone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-1 beta production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-17 production NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of leukocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of natural killer cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric-oxide synthase biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of nitric-oxide synthase biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of signaling receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynapse to nucleus signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in response to granulocyte macrophage colony-stimulating factor NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to hydroperoxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interleukin-12 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within symbiont-induced defense-related programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in type II interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tyrosine phosphorylation of STAT protein IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of granulocyte macrophage colony-stimulating factor receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of interleukin-12 receptor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of interleukin-23 receptor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase JAK2
    Names
    JAK-2
    NP_001041642.1
    NP_032439.2
    XP_006526776.1
    XP_006526777.1
    XP_006526778.1
    XP_011245457.1
    XP_017173557.1
    XP_036017342.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048177.3NP_001041642.1  tyrosine-protein kinase JAK2

      See identical proteins and their annotated locations for NP_001041642.1

      Status: VALIDATED

      Source sequence(s)
      AC119228, AC162456
      Consensus CDS
      CCDS37950.1
      UniProtKB/Swiss-Prot
      G5E852, Q62120, Q62124, Q7TQD0
      Related
      ENSMUSP00000025705.7, ENSMUST00000025705.7
      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:8441127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39134
      FERM_F1; FERM F1 ubiquitin-like domain
    2. NM_008413.4NP_032439.2  tyrosine-protein kinase JAK2

      See identical proteins and their annotated locations for NP_032439.2

      Status: VALIDATED

      Source sequence(s)
      AC119228, AC162456
      Consensus CDS
      CCDS37950.1
      UniProtKB/Swiss-Prot
      G5E852, Q62120, Q62124, Q7TQD0
      Related
      ENSMUSP00000064394.4, ENSMUST00000065796.10
      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:8441127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39134
      FERM_F1; FERM F1 ubiquitin-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      29229006..29290495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161449.1XP_036017342.1  tyrosine-protein kinase JAK2 isoform X5

      UniProtKB/TrEMBL
      A0A494BBB9
      Related
      ENSMUSP00000158405.2, ENSMUST00000236990.2
      Conserved Domains (5) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      pfam18377
      Location:143261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39134
      FERM_F1; FERM F1 ubiquitin-like domain
      cl21453
      Location:545592
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006526715.5XP_006526778.1  tyrosine-protein kinase JAK2 isoform X5

      UniProtKB/TrEMBL
      A0A494BBB9
      Conserved Domains (5) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      pfam18377
      Location:143261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39134
      FERM_F1; FERM F1 ubiquitin-like domain
      cl21453
      Location:545592
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006526713.5XP_006526776.1  tyrosine-protein kinase JAK2 isoform X2

      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd14205
      Location:7991082
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39134
      FERM_F1; FERM F1 ubiquitin-like domain
      cl21453
      Location:548761
      PKc_like; Protein Kinases, catalytic domain
    4. XM_011247155.3XP_011245457.1  tyrosine-protein kinase JAK2 isoform X1

      See identical proteins and their annotated locations for XP_011245457.1

      UniProtKB/Swiss-Prot
      G5E852, Q62120, Q62124, Q7TQD0
      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:8441127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39134
      FERM_F1; FERM F1 ubiquitin-like domain
    5. XM_017318068.3XP_017173557.1  tyrosine-protein kinase JAK2 isoform X4

      Conserved Domains (3) summary
      cd05078
      Location:140401
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:439722
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cl15255
      Location:177
      SH2; Src homology 2 (SH2) domain
    6. XM_006526714.5XP_006526777.1  tyrosine-protein kinase JAK2 isoform X3

      Conserved Domains (5) summary
      cd10379
      Location:190286
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:70190
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:349610
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:648931
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:1065
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain