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    Jak1 Janus kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 16451, updated on 18-Nov-2018

    Summary

    Official Symbol
    Jak1provided by MGI
    Official Full Name
    Janus kinase 1provided by MGI
    Primary source
    MGI:MGI:96628
    See related
    Ensembl:ENSMUSG00000028530 Vega:OTTMUSG00000008208
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BAP004; AA960307; C130039L05Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 28.5), spleen adult (RPKM 26.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Jak1 in Genome Data Viewer
    Location:
    4 C6; 4 46.19 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (101151974..101265291, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (100824579..100937887, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene cache domain containing 1 Neighboring gene predicted gene, 35956 Neighboring gene ribonucleoprotein, PTB-binding 2 Neighboring gene proteasome (prosome, macropain) subunit, beta type 2 pseudogene Neighboring gene RIKEN cDNA E130102H24 gene Neighboring gene RIKEN cDNA 0610043K17 gene Neighboring gene microRNA 101a Neighboring gene ribosomal protein L9 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC37919

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    CCR5 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    growth hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    growth hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to interleukin-3 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to interleukin-7 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme linked receptor protein signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-2-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of STAT cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase JAK1
    Names
    JAK-1
    NP_666257.2
    XP_006502875.1
    XP_011238753.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146145.2NP_666257.2  tyrosine-protein kinase JAK1

      See identical proteins and their annotated locations for NP_666257.2

      Status: VALIDATED

      Source sequence(s)
      AK141210, AK152128, AL627251, AL645668
      Consensus CDS
      CCDS18393.1
      UniProtKB/TrEMBL
      B1ASP2, Q3U8P8, Q3URU8
      Related
      ENSMUSP00000099842.3, OTTMUSP00000008566, ENSMUST00000102781.9, OTTMUST00000018649
      Conserved Domains (6) summary
      cd05079
      Location:8691152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd10378
      Location:426526
      SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
      smart00295
      Location:37286
      B41; Band 4.1 homologues
      cd05077
      Location:582845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282426
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      pfam07714
      Location:8741146
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      101151974..101265291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502812.3XP_006502875.1  tyrosine-protein kinase JAK1 isoform X1

      See identical proteins and their annotated locations for XP_006502875.1

      UniProtKB/TrEMBL
      B1ASP2
      Conserved Domains (6) summary
      cd05079
      Location:8691152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd10378
      Location:426526
      SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
      smart00295
      Location:37286
      B41; Band 4.1 homologues
      cd05077
      Location:582845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282426
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      pfam07714
      Location:8741146
      Pkinase_Tyr; Protein tyrosine kinase
    2. XM_011240451.2XP_011238753.1  tyrosine-protein kinase JAK1 isoform X1

      See identical proteins and their annotated locations for XP_011238753.1

      UniProtKB/TrEMBL
      B1ASP2
      Conserved Domains (6) summary
      cd05079
      Location:8691152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd10378
      Location:426526
      SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
      smart00295
      Location:37286
      B41; Band 4.1 homologues
      cd05077
      Location:582845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282426
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      pfam07714
      Location:8741146
      Pkinase_Tyr; Protein tyrosine kinase
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