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    Jag2 jagged 2 [ Mus musculus (house mouse) ]

    Gene ID: 16450, updated on 24-Aug-2021

    Summary

    Official Symbol
    Jag2provided by MGI
    Official Full Name
    jagged 2provided by MGI
    Primary source
    MGI:MGI:1098270
    See related
    Ensembl:ENSMUSG00000002799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Se; sm; Serh; D12Ggc2e; mJagged2-1
    Expression
    Ubiquitous expression in lung adult (RPKM 17.9), ovary adult (RPKM 17.4) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Jag2 in Genome Data Viewer
    Location:
    12 F1; 12 61.37 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112871423..112893432, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112907803..112929812, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (114146801..114167706, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 132 Neighboring gene RIKEN cDNA 1700127F24 gene Neighboring gene predicted gene, 30461 Neighboring gene microRNA 6941 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 14 Neighboring gene BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit Neighboring gene BTB (POZ) domain containing 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Notch binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in auditory receptor cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell fate determination NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within epithelial cell apoptotic process involved in palatal shelf morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gamma-delta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within respiratory system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sensory perception of sound NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thymic T cell selection ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    protein jagged-2
    Names
    syndactylism

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010588.2NP_034718.2  protein jagged-2 precursor

      See identical proteins and their annotated locations for NP_034718.2

      Status: VALIDATED

      Source sequence(s)
      AC160929
      Consensus CDS
      CCDS26200.1
      UniProtKB/Swiss-Prot
      Q9QYE5
      Related
      ENSMUSP00000075224.4, ENSMUST00000075827.5
      Conserved Domains (5) summary
      smart00215
      Location:872943
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:827863
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:351381
      EGF; EGF-like domain
      pfam01414
      Location:178240
      DSL; Delta serrate ligand
      pfam07657
      Location:28102
      MNNL; N terminus of Notch ligand

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      112871423..112893432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515486.3XP_006515549.1  protein jagged-2 isoform X3

      Conserved Domains (5) summary
      smart00215
      Location:834905
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:423458
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:351381
      EGF; EGF-like domain
      pfam01414
      Location:178240
      DSL; Delta serrate ligand
      pfam07657
      Location:28103
      MNNL; N-terminus of Notch ligand
    2. XM_011243999.2XP_011242301.1  protein jagged-2 isoform X2

      Conserved Domains (5) summary
      smart00215
      Location:841912
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:430465
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:358388
      EGF; EGF-like domain
      pfam01414
      Location:185247
      DSL; Delta serrate ligand
      pfam07657
      Location:28103
      MNNL; N-terminus of Notch ligand
    3. XM_011243998.2XP_011242300.1  protein jagged-2 isoform X1

      Conserved Domains (5) summary
      smart00215
      Location:879950
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:834870
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:358388
      EGF; EGF-like domain
      pfam01414
      Location:185247
      DSL; Delta serrate ligand
      pfam07657
      Location:28103
      MNNL; N-terminus of Notch ligand

    RNA

    1. XR_004937414.1 RNA Sequence

    2. XR_004937413.1 RNA Sequence

    3. XR_872707.3 RNA Sequence

    4. XR_872705.2 RNA Sequence

    5. XR_004937415.1 RNA Sequence

    6. XR_872706.2 RNA Sequence

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