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    Itsn1 intersectin 1 (SH3 domain protein 1A) [ Mus musculus (house mouse) ]

    Gene ID: 16443, updated on 9-Sep-2018

    Summary

    Official Symbol
    Itsn1provided by MGI
    Official Full Name
    intersectin 1 (SH3 domain protein 1A)provided by MGI
    Primary source
    MGI:MGI:1338069
    See related
    Ensembl:ENSMUSG00000022957 Vega:OTTMUSG00000021345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ese1; Itsn; Ehsh1; Sh3p17; AA517634; AA545208; AI316805; AI839402; AI848451
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.3), CNS E14 (RPKM 6.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Itsn1 in Genome Data Viewer
    Location:
    16; 16 C4
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (91729353..91920591)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (91729616..91920824)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene 10785 Neighboring gene crystallin, zeta (quinone reductase)-like 1 Neighboring gene predicted gene, 46543 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit Neighboring gene predicted gene, 36797

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rho guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of caveolin-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    apical dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    calyx of Held IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic endocytic zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    intersectin-1
    Names
    EH and SH3 domains protein 1
    Eh domain, SH3 domain regulator of endocytosis 1
    intersectin (SH3 domain protein 1A)
    intersectin short form 2 variant 2
    intersectin-L

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110275.1NP_001103745.1  intersectin-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 3' end, compared to variant 1. These differences produce a unique 3' UTR and result in a protein (isoform 2) that is shorter at the C-terminus, compared to isoform 1.
      Source sequence(s)
      AF132478, BC062938
      Consensus CDS
      CCDS49913.1
      UniProtKB/Swiss-Prot
      Q9Z0R4
      Related
      ENSMUSP00000056011.7, OTTMUSP00000023654, ENSMUST00000056482.13, OTTMUST00000050609
      Conserved Domains (11) summary
      smart00027
      Location:214309
      EH; Eps15 homology domain
      cd11987
      Location:742796
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11991
      Location:9991050
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11995
      Location:11511204
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG1340
      Location:350646
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:225291
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam16617
      Location:796910
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:677686
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:10671131
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:615706
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:546646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_001110276.1NP_001103746.1  intersectin-1 isoform 3

      See identical proteins and their annotated locations for NP_001103746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the presence and absence of exons at its 3' end, compared to variant 1. These differences produce a unique 3' UTR and result in a shorter protein (isoform 3) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC066105, CB519152
      Consensus CDS
      CCDS49914.1
      UniProtKB/TrEMBL
      Q6NZJ5
      Related
      ENSMUSP00000093598.3, OTTMUSP00000023653, ENSMUST00000095909.9, OTTMUST00000050608
      Conserved Domains (4) summary
      smart00027
      Location:214309
      EH; Eps15 homology domain
      cd00052
      Location:225291
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam03957
      Location:93190
      Jun; Jun-like transcription factor
      cl23765
      Location:351465
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    3. NM_010587.2NP_034717.2  intersectin-1 isoform 1

      See identical proteins and their annotated locations for NP_034717.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC126053, AF132481, AK082606, BC062938
      Consensus CDS
      CCDS37402.1
      UniProtKB/Swiss-Prot
      Q9Z0R4
      UniProtKB/TrEMBL
      Q8C4B5
      Related
      ENSMUSP00000109635.2, OTTMUSP00000023652, ENSMUST00000114002.8, OTTMUST00000050607
      Conserved Domains (17) summary
      cd08375
      Location:15751709
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:214309
      EH; Eps15 homology domain
      cd11987
      Location:742796
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:910961
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:9991050
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:10671131
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:11511204
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG1340
      Location:350646
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:225291
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:14411572
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00169
      Location:14581564
      PH; PH domain
      pfam00621
      Location:12351415
      RhoGEF; RhoGEF domain
      pfam03957
      Location:93190
      Jun; Jun-like transcription factor
      pfam16617
      Location:796910
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:677686
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:615706
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:546646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      91729353..91920591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522934.3XP_006522997.1  intersectin-1 isoform X4

      UniProtKB/TrEMBL
      E9Q0N0
      Related
      ENSMUSP00000066361.5, OTTMUSP00000023658, ENSMUST00000064797.11, OTTMUST00000050614
      Conserved Domains (17) summary
      cd08375
      Location:15801714
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:214309
      EH; Eps15 homology domain
      cd11989
      Location:915966
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:10041055
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:10721136
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:11561209
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG1340
      Location:350646
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:225291
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:14461577
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00169
      Location:14631569
      PH; PH domain
      pfam00621
      Location:12401420
      RhoGEF; RhoGEF domain
      pfam03957
      Location:93190
      Jun; Jun-like transcription factor
      pfam16617
      Location:801915
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:677686
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:742801
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:615706
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:546646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. XM_006522935.2XP_006522998.1  intersectin-1 isoform X5

      Conserved Domains (16) summary
      cd08375
      Location:15331667
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11987
      Location:766825
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:939990
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11995
      Location:11091162
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG1340
      Location:374670
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:13991530
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00169
      Location:14161522
      PH; PH domain
      pfam00621
      Location:11931373
      RhoGEF; RhoGEF domain
      pfam03957
      Location:117214
      Jun; Jun-like transcription factor
      pfam16617
      Location:825939
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:701710
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:10281089
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:639730
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:570670
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. XM_006522933.2XP_006522996.1  intersectin-1 isoform X3

      Conserved Domains (17) summary
      cd08375
      Location:15991733
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11987
      Location:766820
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:934985
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:10231074
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:10911155
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:11751228
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG1340
      Location:374670
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:14651596
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00169
      Location:14821588
      PH; PH domain
      pfam00621
      Location:12591439
      RhoGEF; RhoGEF domain
      pfam03957
      Location:117214
      Jun; Jun-like transcription factor
      pfam16617
      Location:820934
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:701710
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:639730
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:570670
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    4. XM_006522936.2XP_006522999.1  intersectin-1 isoform X6

      Conserved Domains (16) summary
      cd08375
      Location:15281662
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11987
      Location:766820
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:934985
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11995
      Location:11041157
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG1340
      Location:374670
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:13941525
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00169
      Location:14111517
      PH; PH domain
      pfam00621
      Location:11881368
      RhoGEF; RhoGEF domain
      pfam03957
      Location:117214
      Jun; Jun-like transcription factor
      pfam16617
      Location:820934
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:701710
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:10231084
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:639730
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:570670
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    5. XM_006522938.2XP_006523001.1  intersectin-1 isoform X8

      Conserved Domains (11) summary
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11991
      Location:10281079
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11995
      Location:11801233
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG1340
      Location:374670
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam03957
      Location:117214
      Jun; Jun-like transcription factor
      pfam16617
      Location:825939
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:701710
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:10961160
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:639730
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:570670
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    6. XM_006522939.2XP_006523002.1  intersectin-1 isoform X9

      Conserved Domains (12) summary
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11987
      Location:766820
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11991
      Location:10231074
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11995
      Location:11751228
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG1340
      Location:374670
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam03957
      Location:117214
      Jun; Jun-like transcription factor
      pfam16617
      Location:820934
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:701710
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:10911155
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:639730
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:570670
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    7. XM_011246102.2XP_011244404.1  intersectin-1 isoform X11

      See identical proteins and their annotated locations for XP_011244404.1

      Conserved Domains (10) summary
      smart00027
      Location:238333
      EH; Eps15 homology domain
      COG1340
      Location:374670
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam03957
      Location:117214
      Jun; Jun-like transcription factor
      pfam16617
      Location:825939
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:701710
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:766825
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:639730
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:570670
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23765
      Location:375489
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    8. XM_006522940.2XP_006523003.1  intersectin-1 isoform X10

      Conserved Domains (8) summary
      smart00027
      Location:238333
      EH; Eps15 homology domain
      COG1340
      Location:374670
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam16617
      Location:825931
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:701710
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:766825
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:639730
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:570670
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    9. XM_006522931.2XP_006522994.1  intersectin-1 isoform X1

      Conserved Domains (17) summary
      cd08375
      Location:16041738
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11989
      Location:939990
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:10281079
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:10961160
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:11801233
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG1340
      Location:374670
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:14701601
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00169
      Location:14871593
      PH; PH domain
      pfam00621
      Location:12641444
      RhoGEF; RhoGEF domain
      pfam03957
      Location:117214
      Jun; Jun-like transcription factor
      pfam16617
      Location:825939
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:701710
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:766825
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:639730
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:570670
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    10. XM_006522932.3XP_006522995.1  intersectin-1 isoform X2

      Conserved Domains (17) summary
      cd08375
      Location:16021736
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:236331
      EH; Eps15 homology domain
      cd11989
      Location:937988
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:10261077
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:10941158
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:11781231
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG1340
      Location:372668
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:247313
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:14681599
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00169
      Location:14851591
      PH; PH domain
      pfam00621
      Location:12621442
      RhoGEF; RhoGEF domain
      pfam03957
      Location:115212
      Jun; Jun-like transcription factor
      pfam16617
      Location:823937
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:699708
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:764823
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:637728
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:568668
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    11. XM_006522937.3XP_006523000.1  intersectin-1 isoform X7

      Conserved Domains (15) summary
      cd08375
      Location:13871521
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:21116
      EH; Eps15 homology domain
      cd11991
      Location:811862
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:879943
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:9631016
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00052
      Location:3298
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:12531384
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00169
      Location:12701376
      PH; PH domain
      pfam00621
      Location:10471227
      RhoGEF; RhoGEF domain
      pfam05914
      Location:179487
      RIB43A; RIB43A
      pfam16617
      Location:608722
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:484493
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:549608
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:422513
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:353453
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RNA

    1. XR_001781793.1 RNA Sequence

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