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    Itsn1 intersectin 1 (SH3 domain protein 1A) [ Mus musculus (house mouse) ]

    Gene ID: 16443, updated on 5-Sep-2021

    Summary

    Official Symbol
    Itsn1provided by MGI
    Official Full Name
    intersectin 1 (SH3 domain protein 1A)provided by MGI
    Primary source
    MGI:MGI:1338069
    See related
    Ensembl:ENSMUSG00000022957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ese; EHSH; Ese1; Itsn; Sh3p; Ehsh1; Sh3p17; AA517634; AA545208; AI316805; AI839402; AI848451
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.3), CNS E14 (RPKM 6.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Itsn1 in Genome Data Viewer
    Location:
    16; 16 C4
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91526198..91717479)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91729310..91920591)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (91729616..91920824)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10785 Neighboring gene crystallin, zeta (quinone reductase)-like 1 Neighboring gene predicted gene, 46543 Neighboring gene predicted gene, 53921 Neighboring gene predicted gene, 52262 Neighboring gene predicted gene, 25245 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clathrin-dependent synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of caveolin-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in calyx of Held IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic endocytic zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    intersectin-1
    Names
    EH and SH3 domains protein 1
    Eh domain, SH3 domain regulator of endocytosis 1
    intersectin (SH3 domain protein 1A)
    intersectin short form 2 variant 2
    intersectin-L

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110275.1NP_001103745.1  intersectin-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 3' end, compared to variant 1. These differences produce a unique 3' UTR and result in a protein (isoform 2) that is shorter at the C-terminus, compared to isoform 1.
      Source sequence(s)
      AF132478, BC062938
      Consensus CDS
      CCDS49913.1
      UniProtKB/Swiss-Prot
      Q9Z0R4
      Related
      ENSMUSP00000056011.8, ENSMUST00000056482.14
      Conserved Domains (11) summary
      smart00027
      Location:214309
      EH; Eps15 homology domain
      cd11987
      Location:742796
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11991
      Location:9991050
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11995
      Location:11511204
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG1340
      Location:350646
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:225291
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam16617
      Location:796910
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:677686
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:10671131
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:615706
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:546646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_001110276.1NP_001103746.1  intersectin-1 isoform 3

      See identical proteins and their annotated locations for NP_001103746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the presence and absence of exons at its 3' end, compared to variant 1. These differences produce a unique 3' UTR and result in a shorter protein (isoform 3) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC066105, CB519152
      Consensus CDS
      CCDS49914.1
      UniProtKB/TrEMBL
      Q6NZJ5
      Related
      ENSMUSP00000093598.4, ENSMUST00000095909.10
      Conserved Domains (4) summary
      smart00027
      Location:214309
      EH; Eps15 homology domain
      cd00052
      Location:225291
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam03957
      Location:93190
      Jun; Jun-like transcription factor
      cl23765
      Location:351465
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    3. NM_010587.2NP_034717.2  intersectin-1 isoform 1

      See identical proteins and their annotated locations for NP_034717.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC126053, AF132481, AK082606, BC062938
      Consensus CDS
      CCDS37402.1
      UniProtKB/Swiss-Prot
      Q9Z0R4
      UniProtKB/TrEMBL
      Q8C4B5
      Related
      ENSMUSP00000109635.3, ENSMUST00000114002.9
      Conserved Domains (17) summary
      cd08375
      Location:15751709
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:214309
      EH; Eps15 homology domain
      cd11987
      Location:742796
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:910961
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:9991050
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:10671131
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:11511204
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG1340
      Location:350646
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00052
      Location:225291
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:14411572
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00169
      Location:14581564
      PH; PH domain
      pfam00621
      Location:12351415
      RhoGEF; RhoGEF domain
      pfam03957
      Location:93190
      Jun; Jun-like transcription factor
      pfam16617
      Location:796910
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:677686
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:615706
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:546646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      91526198..91717479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522934.4XP_006522997.1  intersectin-1 isoform X4

      UniProtKB/TrEMBL
      E9Q0N0
      Related
      ENSMUSP00000066361.6, ENSMUST00000064797.12
      Conserved Domains (12) summary
      PTZ00121
      Location:331715
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:15801714
      C2_Intersectin; C2 domain present in Intersectin
      PRK14959
      Location:42184
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      smart00027
      Location:214309
      EH; Eps15 homology domain
      cd11989
      Location:915966
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:10041055
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:10721136
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:11561209
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00160
      Location:12361419
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:801915
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:14381591
      PH_13; Pleckstrin homology domain
      cl17036
      Location:742801
      SH3; Src Homology 3 domain superfamily
    2. XM_036159794.1XP_036015687.1  intersectin-1 isoform X11

      Related
      ENSMUSP00000109629.2, ENSMUST00000113996.8
      Conserved Domains (7) summary
      PTZ00121
      Location:331715
      PTZ00121; MAEBL; Provisional
      PRK14959
      Location:42184
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      smart00027
      Location:214309
      EH; Eps15 homology domain
      cd11987
      Location:742796
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11995
      Location:10801133
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      pfam16617
      Location:796910
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl17036
      Location:9991060
      SH3; Src Homology 3 domain superfamily
    3. XM_006522931.3XP_006522994.1  intersectin-1 isoform X1

      Conserved Domains (12) summary
      PTZ00121
      Location:355739
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:16041738
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11989
      Location:939990
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:10281079
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:10961160
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:11801233
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:155226
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      cd00160
      Location:12601443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:825939
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:14621615
      PH_13; Pleckstrin homology domain
      cl17036
      Location:766825
      SH3; Src Homology 3 domain superfamily
    4. XM_006522935.2XP_006522998.1  intersectin-1 isoform X5

      Conserved Domains (11) summary
      PTZ00121
      Location:355739
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:15331667
      C2_Intersectin; C2 domain present in Intersectin
      PRK14959
      Location:66208
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11987
      Location:766825
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:939990
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11995
      Location:11091162
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00160
      Location:11891372
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:825939
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13911544
      PH_13; Pleckstrin homology domain
      cl17036
      Location:10281089
      SH3; Src Homology 3 domain superfamily
    5. XM_006522933.2XP_006522996.1  intersectin-1 isoform X3

      Conserved Domains (12) summary
      PTZ00121
      Location:355739
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:15991733
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11987
      Location:766820
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:934985
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:10231074
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:10911155
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:11751228
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:155226
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      cd00160
      Location:12551438
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:820934
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:14571610
      PH_13; Pleckstrin homology domain
    6. XM_006522936.2XP_006522999.1  intersectin-1 isoform X6

      Conserved Domains (11) summary
      PTZ00121
      Location:355739
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:15281662
      C2_Intersectin; C2 domain present in Intersectin
      PRK14959
      Location:66208
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11987
      Location:766820
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:934985
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11995
      Location:11041157
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00160
      Location:11841367
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:820934
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13861539
      PH_13; Pleckstrin homology domain
      cl17036
      Location:10231084
      SH3; Src Homology 3 domain superfamily
    7. XM_006522938.2XP_006523001.1  intersectin-1 isoform X8

      Conserved Domains (7) summary
      PTZ00121
      Location:355739
      PTZ00121; MAEBL; Provisional
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11991
      Location:10281079
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11995
      Location:11801233
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:155226
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      pfam16617
      Location:825939
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl17036
      Location:10961160
      SH3; Src Homology 3 domain superfamily
    8. XM_036159793.1XP_036015686.1  intersectin-1 isoform X10

      Conserved Domains (6) summary
      PTZ00121
      Location:355739
      PTZ00121; MAEBL; Provisional
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11995
      Location:11091162
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:155226
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      pfam16617
      Location:825939
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl17036
      Location:10281089
      SH3; Src Homology 3 domain superfamily
    9. XM_006522939.2XP_006523002.1  intersectin-1 isoform X9

      Conserved Domains (8) summary
      PTZ00121
      Location:355739
      PTZ00121; MAEBL; Provisional
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11987
      Location:766820
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11991
      Location:10231074
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11995
      Location:11751228
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:155226
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      pfam16617
      Location:820934
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl17036
      Location:10911155
      SH3; Src Homology 3 domain superfamily
    10. XM_006522940.2XP_006523003.1  intersectin-1 isoform X12

      Conserved Domains (5) summary
      PTZ00121
      Location:355739
      PTZ00121; MAEBL; Provisional
      smart00027
      Location:238333
      EH; Eps15 homology domain
      PLN02983
      Location:155226
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      pfam16617
      Location:825931
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl17036
      Location:766825
      SH3; Src Homology 3 domain superfamily
    11. XM_036159795.1XP_036015688.1  intersectin-1 isoform X13

      Conserved Domains (5) summary
      PTZ00121
      Location:355739
      PTZ00121; MAEBL; Provisional
      smart00027
      Location:238333
      EH; Eps15 homology domain
      cd11987
      Location:766820
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      pfam16617
      Location:820926
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      NF033761
      Location:117245
      gliding_GltJ; adventurous gliding motility protein GltJ
    12. XM_006522932.5XP_006522995.1  intersectin-1 isoform X2

      Conserved Domains (12) summary
      PTZ00121
      Location:353737
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:16021736
      C2_Intersectin; C2 domain present in Intersectin
      PRK14959
      Location:64206
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      smart00027
      Location:236331
      EH; Eps15 homology domain
      cd11989
      Location:937988
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:10261077
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:10941158
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:11781231
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00160
      Location:12581441
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:823937
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:14601613
      PH_13; Pleckstrin homology domain
      cl17036
      Location:764823
      SH3; Src Homology 3 domain superfamily
    13. XM_006522937.4XP_006523000.1  intersectin-1 isoform X7

      Conserved Domains (10) summary
      PTZ00121
      Location:138522
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:13871521
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:21116
      EH; Eps15 homology domain
      cd11991
      Location:811862
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:879943
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:9631016
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00160
      Location:10431226
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:608722
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:12451398
      PH_13; Pleckstrin homology domain
      cl17036
      Location:549608
      SH3; Src Homology 3 domain superfamily

    RNA

    1. XR_004939167.1 RNA Sequence

    2. XR_004939165.1 RNA Sequence

    3. XR_004939168.1 RNA Sequence

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