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    Itpa inosine triphosphatase (nucleoside triphosphate pyrophosphatase) [ Mus musculus (house mouse) ]

    Gene ID: 16434, updated on 23-Jun-2021

    Summary

    Official Symbol
    Itpaprovided by MGI
    Official Full Name
    inosine triphosphatase (nucleoside triphosphate pyrophosphatase)provided by MGI
    Primary source
    MGI:MGI:96622
    See related
    Ensembl:ENSMUSG00000074797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I; Itp; ITPase; NTPase; AU020102; 2010016I08Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 19.9), CNS E18 (RPKM 18.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Itpa in Genome Data Viewer
    Location:
    2 F1; 2 63.24 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130506702..130523534)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130664692..130681614)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (130493577..130507350)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene leucine zipper, putative tumor suppressor family member 3 Neighboring gene DDRGK domain containing 1 Neighboring gene solute carrier family 4, sodium bicarbonate transporter-like, member 11 Neighboring gene dynein axonemal assembly factor 9 Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADH pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dITP diphosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables dTTP diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleoside-triphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleoside-triphosphate diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within ITP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleoside triphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inosine triphosphate pyrophosphatase
    Names
    non-canonical purine NTP pyrophosphatase
    non-standard purine NTP pyrophosphatase
    nucleoside triphosphate pyrophosphatase
    nucleoside-triphosphate diphosphatase
    NP_001349577.1
    NP_080198.2
    XP_017171220.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362648.1NP_001349577.1  inosine triphosphate pyrophosphatase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK153806, BC026508, BY255189
      Conserved Domains (1) summary
      pfam01725
      Location:15114
      Ham1p_like; Ham1 family
    2. NM_025922.3NP_080198.2  inosine triphosphate pyrophosphatase isoform 1

      See identical proteins and their annotated locations for NP_080198.2

      Status: VALIDATED

      Source sequence(s)
      AK153806, BC026508
      Consensus CDS
      CCDS16748.1
      UniProtKB/Swiss-Prot
      Q9D892
      UniProtKB/TrEMBL
      Q60I30
      Related
      ENSMUSP00000099482.5, ENSMUST00000103193.5
      Conserved Domains (1) summary
      cd00515
      Location:10188
      HAM1; NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      130506702..130523534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315731.3XP_017171220.1  inosine triphosphate pyrophosphatase isoform X1

      UniProtKB/Swiss-Prot
      Q9D892
      UniProtKB/TrEMBL
      Q60I30
      Conserved Domains (1) summary
      cd00515
      Location:10188
      HAM1; NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A ...
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