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    Eif6 eukaryotic translation initiation factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 16418, updated on 6-Sep-2021

    Summary

    Official Symbol
    Eif6provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 6provided by MGI
    Primary source
    MGI:MGI:1196288
    See related
    Ensembl:ENSMUSG00000027613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAB; eIF; p27B; Itgb4; eIF-6; imc-41; p27BBP; Itgb4bp; imc-415; AA408895; p27(BBP); 1110004P11
    Summary
    The protein encoded by this gene is a eukaryotic translation initiation factor that regulates both ribosome biogenesis and translation, which are rate-limiting factors for cell growth. The encoded protein binds 60S ribosomes and prevents their association with 40S ribosomes. This gene may play a role in oncogenesis as well. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 138.5), small intestine adult (RPKM 124.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Eif6 in Genome Data Viewer
    Location:
    2; 2 H1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155661757..155668845, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155819837..155826925, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (155645573..155652661, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 24 Neighboring gene predicted gene, 46772 Neighboring gene cDNA sequence BC029722 Neighboring gene family with sequence similarity 83, member C Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 1 Neighboring gene predicted gene, 54125

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in assembly of large subunit precursor of preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mature ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in miRNA mediated inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of megakaryocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to insulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intermediate filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 6
    Names
    B4 integrin interactor
    integrin beta 4 binding protein
    NP_034709.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010579.2NP_034709.1  eukaryotic translation initiation factor 6

      See identical proteins and their annotated locations for NP_034709.1

      Status: REVIEWED

      Source sequence(s)
      AL845445, AL929233, BX004872
      Consensus CDS
      CCDS16956.1
      UniProtKB/Swiss-Prot
      O55135
      UniProtKB/TrEMBL
      Q545K4
      Related
      ENSMUSP00000029142.9, ENSMUST00000029142.15
      Conserved Domains (1) summary
      PTZ00136
      Location:1244
      PTZ00136; eukaryotic translation initiation factor 6-like protein; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155661757..155668845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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