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    Eif6 eukaryotic translation initiation factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 16418, updated on 31-Jan-2019

    Summary

    Official Symbol
    Eif6provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 6provided by MGI
    Primary source
    MGI:MGI:1196288
    See related
    Ensembl:ENSMUSG00000027613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAB; eIF-6; p27BBP; Itgb4bp; imc-415; AA408895; p27(BBP); 1110004P11
    Summary
    The protein encoded by this gene is a eukaryotic translation initiation factor that regulates both ribosome biogenesis and translation, which are rate-limiting factors for cell growth. The encoded protein binds 60S ribosomes and prevents their association with 40S ribosomes. This gene may play a role in oncogenesis as well. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 138.5), small intestine adult (RPKM 124.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Eif6 in Genome Data Viewer
    Location:
    2; 2 H1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (155819837..155826925, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (155645573..155652661, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 24 Neighboring gene predicted gene, 46772 Neighboring gene cDNA sequence BC029722 Neighboring gene family with sequence similarity 83, member C Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystemIntegrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands...
    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystem
      Translation Factors

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    assembly of large subunit precursor of preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    mature ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    miRNA mediated inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of megakaryocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to insulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intermediate filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 6
    Names
    B4 integrin interactor
    integrin beta 4 binding protein
    NP_034709.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010579.2NP_034709.1  eukaryotic translation initiation factor 6

      See identical proteins and their annotated locations for NP_034709.1

      Status: REVIEWED

      Source sequence(s)
      AL845445, AL929233, BX004872
      Consensus CDS
      CCDS16956.1
      UniProtKB/Swiss-Prot
      O55135
      UniProtKB/TrEMBL
      Q545K4
      Related
      ENSMUSP00000029142.8, ENSMUST00000029142.14
      Conserved Domains (1) summary
      PTZ00136
      Location:1244
      PTZ00136; eukaryotic translation initiation factor 6-like protein; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      155819837..155826925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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