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    Itgb1bp1 integrin beta 1 binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 16413, updated on 31-Jan-2019

    Summary

    Official Symbol
    Itgb1bp1provided by MGI
    Official Full Name
    integrin beta 1 binding protein 1provided by MGI
    Primary source
    MGI:MGI:1306802
    See related
    Ensembl:ENSMUSG00000062352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Icap1; AI449260; AU019480
    Expression
    Ubiquitous expression in testis adult (RPKM 30.9), subcutaneous fat pad adult (RPKM 11.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See Itgb1bp1 in Genome Data Viewer
    Location:
    12; 12 A1.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (21267246..21286279, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (21275667..21292098, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene 5977 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Neighboring gene predicted gene, 40855 Neighboring gene cleavage and polyadenylation specificity factor 3 Neighboring gene a disintegrin and metallopeptidase domain 17 Neighboring gene isoamyl acetate-hydrolyzing esterase 1 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GDP-dissociation inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    biomineral tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to fibroblast growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    integrin activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    myoblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell adhesion involved in substrate-bound cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fibroblast migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    receptor clustering IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood vessel size ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tube formation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    integrin beta-1-binding protein 1
    Names
    bodenin
    integrin cytoplasmic domain-associated protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355609.1NP_001342538.1  integrin beta-1-binding protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK007635, AK075577, BE947737, BY085309, CX238278
      Conserved Domains (1) summary
      cl17171
      Location:1199
      PH-like; Pleckstrin homology-like domain
    2. NM_008403.5NP_032429.1  integrin beta-1-binding protein 1

      See identical proteins and their annotated locations for NP_032429.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC156032, AK075577, BE947737, BY085309
      Consensus CDS
      CCDS25833.1
      UniProtKB/Swiss-Prot
      O35671
      Related
      ENSMUSP00000075609.4, ENSMUST00000076260.11
      Conserved Domains (1) summary
      cl17171
      Location:1199
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      21267246..21286279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514989.2XP_006515052.1  integrin beta-1-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006515052.1

      Conserved Domains (1) summary
      cl17171
      Location:1177
      PH-like; Pleckstrin homology-like domain
    2. XM_006514990.3XP_006515053.1  integrin beta-1-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006515053.1

      Conserved Domains (1) summary
      cl17171
      Location:1177
      PH-like; Pleckstrin homology-like domain
    3. XM_006514991.3XP_006515054.1  integrin beta-1-binding protein 1 isoform X2

      UniProtKB/Swiss-Prot
      O35671
      Related
      ENSMUSP00000134627.1, ENSMUST00000173729.7
      Conserved Domains (1) summary
      cl17171
      Location:1199
      PH-like; Pleckstrin homology-like domain
    4. XM_011243816.2XP_011242118.1  integrin beta-1-binding protein 1 isoform X3

      Related
      ENSMUSP00000134508.1, ENSMUST00000172834.1
      Conserved Domains (1) summary
      cl17171
      Location:1177
      PH-like; Pleckstrin homology-like domain
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