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    Itga4 integrin alpha 4 [ Mus musculus (house mouse) ]

    Gene ID: 16401, updated on 11-Nov-2019

    Summary

    Official Symbol
    Itga4provided by MGI
    Official Full Name
    integrin alpha 4provided by MGI
    Primary source
    MGI:MGI:96603
    See related
    Ensembl:ENSMUSG00000027009
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD49D; Itga4B
    Expression
    Broad expression in liver E14 (RPKM 10.1), liver E14.5 (RPKM 9.6) and 17 other tissues See more
    Orthologs

    Genomic context

    See Itga4 in Genome Data Viewer
    Location:
    2 C3; 2 47.38 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (79255426..79333114)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (79095583..79173271)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 1 (chaperonin) pseudogene 14 Neighboring gene predicted gene, 39866 Neighboring gene predicted gene, 35813 Neighboring gene ceramide kinase-like Neighboring gene predicted gene, 22606 Neighboring gene tubulin, beta 6 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to C-X3-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    fibronectin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis involved in innervation ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell adhesion in response to extracellular stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-matrix adhesion involved in ameboidal cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    chorio-allantoic fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    clathrin-dependent extracellular exosome endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    diapedesis ISO
    Inferred from Sequence Orthology
    more info
     
    face development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    import into cell ISO
    Inferred from Sequence Orthology
    more info
     
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    mesenchyme development TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    visceral serous pericardium development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integrin alpha4-beta7 complex ISO
    Inferred from Sequence Orthology
    more info
     
    integrin complex IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    integrin alpha-4
    Names
    CD49 antigen-like family member D
    LPAM subunit alpha
    VLA-4 receptor, alpha 4 subunit
    VLA-4 subunit alpha
    integrin alpha-IV
    integrin alpha4B
    lymphocyte Peyer patch adhesion molecules subunit alpha

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010576.4NP_034706.3  integrin alpha-4 precursor

      See identical proteins and their annotated locations for NP_034706.3

      Status: VALIDATED

      Source sequence(s)
      AL844590
      Consensus CDS
      CCDS16168.1
      UniProtKB/Swiss-Prot
      Q00651
      UniProtKB/TrEMBL
      Q792F9, Q8BQ25
      Related
      ENSMUSP00000099718.3, ENSMUST00000099972.4
      Conserved Domains (2) summary
      smart00191
      Location:366418
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:463902
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p6 C57BL/6J

      Range
      79255426..79333114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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