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    Itch itchy, E3 ubiquitin protein ligase [ Mus musculus (house mouse) ]

    Gene ID: 16396, updated on 23-Jun-2021

    Summary

    Official Symbol
    Itchprovided by MGI
    Official Full Name
    itchy, E3 ubiquitin protein ligaseprovided by MGI
    Primary source
    MGI:MGI:1202301
    See related
    Ensembl:ENSMUSG00000027598
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; AIP4; A130065M08; 6720481N21Rik; 8030492O04Rik; C230047C07Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 9.0), CNS E11.5 (RPKM 8.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Itch in Genome Data Viewer
    Location:
    2 H1; 2 76.94 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (154975401..155068775)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155133481..155226855)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (154959217..155052590)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene S-adenosylhomocysteine hydrolase Neighboring gene predicted gene, 39966 Neighboring gene predicted gene 45609 Neighboring gene RIKEN cDNA 2310005A03 gene Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene predicted gene, 52565 Neighboring gene dynein light chain roadblock-type 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • KIAA4011

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CXCR chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables arrestin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell anergy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K29-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K29-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K48-linked ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISA
    Inferred from Sequence Alignment
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase Itchy
    Names
    HECT-type E3 ubiquitin transferase Itchy homolog
    NP_001230641.1
    NP_032421.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243712.1NP_001230641.1  E3 ubiquitin-protein ligase Itchy

      See identical proteins and their annotated locations for NP_001230641.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL845429, AL929588
      Consensus CDS
      CCDS38293.1
      UniProtKB/Swiss-Prot
      Q8C863
      Related
      ENSMUSP00000105307.2, ENSMUST00000109685.8
      Conserved Domains (5) summary
      cd04021
      Location:17140
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00456
      Location:440471
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:533861
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:509862
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:401430
      WW; WW domain
    2. NM_008395.3NP_032421.2  E3 ubiquitin-protein ligase Itchy

      See identical proteins and their annotated locations for NP_032421.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC062934, BF453521, CJ122836
      Consensus CDS
      CCDS38293.1
      UniProtKB/Swiss-Prot
      Q8C863
      Related
      ENSMUSP00000029126.9, ENSMUST00000029126.15
      Conserved Domains (5) summary
      cd04021
      Location:17140
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00456
      Location:440471
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:533861
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:509862
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:401430
      WW; WW domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      154975401..155068775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004938410.1 RNA Sequence

    2. XR_004938411.1 RNA Sequence

    3. XR_001781069.2 RNA Sequence

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