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    CITED4 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 [ Homo sapiens (human) ]

    Gene ID: 163732, updated on 17-Jun-2024

    Summary

    Official Symbol
    CITED4provided by HGNC
    Official Full Name
    Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4provided by HGNC
    Primary source
    HGNC:HGNC:18696
    See related
    Ensembl:ENSG00000179862 MIM:606815; AllianceGenome:HGNC:18696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]
    Orthologs
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    Genomic context

    See CITED4 in Genome Data Viewer
    Location:
    1p34.2; 1p35-p34
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40861054..40862363, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40730294..40731603, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (41326726..41328035, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily Q member 4 Neighboring gene RNA, 7SL, cytoplasmic 326, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41279047-41279546 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41286429-41286930 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41290219-41291122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41300271-41300796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41305349-41305957 Neighboring gene uncharacterized LOC105378676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 736 Neighboring gene uncharacterized LOC124904157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 737 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 857 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41330845-41331394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41331395-41331944 Neighboring gene Sharpr-MPRA regulatory region 4660 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:41340995-41342194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41347079-41347578 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:41349491-41349992 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:41363720-41364919 Neighboring gene Sharpr-MPRA regulatory region 1319 Neighboring gene protein phosphatase 2 catalytic subunit alpha pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estrogen ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cbp/p300-interacting transactivator 4
    Names
    MRG-2
    MSG1-related protein 2
    transcriptional co-activator 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133467.3NP_597724.1  cbp/p300-interacting transactivator 4

      See identical proteins and their annotated locations for NP_597724.1

      Status: VALIDATED

      Source sequence(s)
      AC119677, BC052559
      Consensus CDS
      CCDS458.1
      UniProtKB/Swiss-Prot
      Q96RK1
      Related
      ENSP00000361721.2, ENST00000372638.4
      Conserved Domains (1) summary
      pfam04487
      Location:1184
      CITED; CITED

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      40861054..40862363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      40730294..40731603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)