Format

Send to:

Choose Destination
    • Showing Current items.

    Il7 interleukin 7 [ Mus musculus (house mouse) ]

    Gene ID: 16196, updated on 23-Jun-2021

    Summary

    Official Symbol
    Il7provided by MGI
    Official Full Name
    interleukin 7provided by MGI
    Primary source
    MGI:MGI:96561
    See related
    Ensembl:ENSMUSG00000040329
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il; Il-7; hlb36; hlb368; A630026I06Rik
    Summary
    The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in thymus adult (RPKM 2.5), spleen adult (RPKM 1.2) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Il7 in Genome Data Viewer
    Location:
    3 A1; 3 2.02 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (7637088..7678820, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (7572028..7613760, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (7572077..7613427, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23592 Neighboring gene zinc finger, C2HC-type containing 1A Neighboring gene predicted gene, 16685 Neighboring gene RIKEN cDNA 1700010I02 gene Neighboring gene predicted gene, 29747

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC129342

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables interleukin-7 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell lineage commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within bone resorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of B cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of B cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of organ growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313888.1NP_001300817.1  interleukin-7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon near the 5' end compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (b) with a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK040399, AK052452
      Consensus CDS
      CCDS84608.1
      UniProtKB/TrEMBL
      Q3UT18
      Related
      ENSMUSP00000141508.2, ENSMUST00000192202.6
      Conserved Domains (1) summary
      cl11602
      Location:1111
      IL7; Interleukin 7/9 family
    2. NM_001313889.1NP_001300818.1  interleukin-7 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon near the 5' end and an alternate internal exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (c) with a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK040399, AK042009, AK052452
      Conserved Domains (1) summary
      cl11602
      Location:1102
      IL7; Interleukin 7/9 family
    3. NM_001313890.1NP_001300819.1  interleukin-7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains two alternate exons in place of the first exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (b) with a shorter N-terminus, compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
      Source sequence(s)
      AK040399, AK139858
      Consensus CDS
      CCDS84608.1
      UniProtKB/TrEMBL
      Q3UT18
      Related
      ENSMUSP00000141827.2, ENSMUST00000194184.6
      Conserved Domains (1) summary
      cl11602
      Location:1111
      IL7; Interleukin 7/9 family
    4. NM_008371.5NP_032397.1  interleukin-7 isoform a precursor

      See identical proteins and their annotated locations for NP_032397.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK040399, AK041307, AK052452
      Consensus CDS
      CCDS50859.1
      UniProtKB/Swiss-Prot
      P10168
      UniProtKB/TrEMBL
      Q544C8
      Related
      ENSMUSP00000141845.2, ENSMUST00000194279.6
      Conserved Domains (1) summary
      smart00127
      Location:27152
      IL7; Interleukin-7 and interleukin-9 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      7637088..7678820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center