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    Il13 interleukin 13 [ Mus musculus (house mouse) ]

    Gene ID: 16163, updated on 26-Jun-2024

    Summary

    Official Symbol
    Il13provided by MGI
    Official Full Name
    interleukin 13provided by MGI
    Primary source
    MGI:MGI:96541
    See related
    Ensembl:ENSMUSG00000020383 AllianceGenome:MGI:96541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il-13
    Summary
    Predicted to enable interleukin-13 receptor binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation. Acts upstream of or within cellular response to cytokine stimulus; inflammatory response; and positive regulation of immune effector process. Located in cytoplasm; external side of plasma membrane; and extracellular space. Is expressed in gut; liver; male reproductive gland or organ; and thymus. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 2.8), testis adult (RPKM 0.6) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Il13 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.98 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53522150..53525529, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53631323..53634702, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A430108G06 gene Neighboring gene kinesin family member 3A Neighboring gene STARR-seq mESC enhancer starr_29488 Neighboring gene STARR-seq mESC enhancer starr_29489 Neighboring gene origin of replication in Il13 Neighboring gene interleukin 4 Neighboring gene ribosomal protein S2, pseudogene 4 Neighboring gene Th2 cytokine locus control region Neighboring gene RAD50 double strand break repair protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (12)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-13 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macrophage activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of complement-dependent cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transforming growth factor beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of connective tissue growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of immunoglobulin production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mast cell degranulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of monoatomic ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of pancreatic stellate cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of proton transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interleukin-13
    Names
    T-cell activation protein P600

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008355.3NP_032381.1  interleukin-13 precursor

      See identical proteins and their annotated locations for NP_032381.1

      Status: VALIDATED

      Source sequence(s)
      AA646049, M23504
      Consensus CDS
      CCDS24683.1
      UniProtKB/Swiss-Prot
      P20109
      Related
      ENSMUSP00000020650.2, ENSMUST00000020650.2
      Conserved Domains (1) summary
      pfam03487
      Location:21130
      IL13; Interleukin-13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      53522150..53525529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)