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    DAO D-amino acid oxidase [ Homo sapiens (human) ]

    Gene ID: 1610, updated on 17-Jun-2024

    Summary

    Official Symbol
    DAOprovided by HGNC
    Official Full Name
    D-amino acid oxidaseprovided by HGNC
    Primary source
    HGNC:HGNC:2671
    See related
    Ensembl:ENSG00000110887 MIM:124050; AllianceGenome:HGNC:2671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAAO; OXDA; DAMOX
    Summary
    This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in kidney (RPKM 37.6) and liver (RPKM 29.1) See more
    Orthologs
    NEW
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    Genomic context

    See DAO in Genome Data Viewer
    Location:
    12q24.11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108880092..108901043)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108854786..108875798)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109273868..109294819)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:109195372-109196325 Neighboring gene uncharacterized LOC101929204 Neighboring gene slingshot protein phosphatase 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:109199370-109200569 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:109207967-109208570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109221436-109222007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6980 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:109231638-109232837 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109232831-109233432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4836 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:109247741-109248940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109250055-109250556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6982 Neighboring gene microRNA 619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4837 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109273628-109274245 Neighboring gene MPRA-validated peak1937 silencer Neighboring gene uncharacterized LOC124903011 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:109300977-109301477 Neighboring gene NANOG hESC enhancer GRCh37_chr12:109311835-109312350 Neighboring gene SV2 related protein Neighboring gene RNA, U6 small nuclear 361, pseudogene Neighboring gene uncharacterized LOC105378256

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC35381

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables D-amino-acid oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables D-amino-acid oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables D-amino-acid oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables FAD binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in D-alanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in D-alanine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in D-amino acid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in D-serine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in D-serine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in D-serine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in digestion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dopamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neutrophil-mediated killing of gram-negative bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proline catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proline catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisomal matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisomal matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in peroxisomal matrix TAS
    Traceable Author Statement
    more info
     
    located_in presynaptic active zone ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    D-amino-acid oxidase
    NP_001400563.1
    NP_001400564.1
    NP_001908.3
    XP_005268749.1
    XP_011536306.1
    XP_054227282.1
    XP_054227283.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023236.1 RefSeqGene

      Range
      5012..25963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001413634.1NP_001400563.1  D-amino-acid oxidase isoform a

      Status: REVIEWED

      Source sequence(s)
      AC087893
      UniProtKB/Swiss-Prot
      B2R7I5, P14920, Q16758, Q8N6R2
      UniProtKB/TrEMBL
      A0A024RBI1, Q7Z312
    2. NM_001413635.1NP_001400564.1  D-amino-acid oxidase isoform b

      Status: REVIEWED

      Source sequence(s)
      AC087893
      UniProtKB/TrEMBL
      A0A0S2Z3J4
    3. NM_001917.5NP_001908.3  D-amino-acid oxidase isoform a

      See identical proteins and their annotated locations for NP_001908.3

      Status: REVIEWED

      Source sequence(s)
      AC087893, BC029057, BM932083, DA085245
      Consensus CDS
      CCDS9122.1
      UniProtKB/Swiss-Prot
      B2R7I5, P14920, Q16758, Q8N6R2
      UniProtKB/TrEMBL
      A0A024RBI1, Q7Z312
      Related
      ENSP00000228476.3, ENST00000228476.8
      Conserved Domains (1) summary
      pfam01266
      Location:2329
      DAO; FAD dependent oxidoreductase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      108880092..108901043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538004.3XP_011536306.1  D-amino-acid oxidase isoform X1

      See identical proteins and their annotated locations for XP_011536306.1

      UniProtKB/Swiss-Prot
      B2R7I5, P14920, Q16758, Q8N6R2
      UniProtKB/TrEMBL
      A0A024RBI1, Q7Z312
      Conserved Domains (1) summary
      pfam01266
      Location:2329
      DAO; FAD dependent oxidoreductase
    2. XM_005268692.5XP_005268749.1  D-amino-acid oxidase isoform X2

      UniProtKB/TrEMBL
      Q7Z312
      Related
      ENSP00000446853.1, ENST00000551281.5
      Conserved Domains (1) summary
      pfam01266
      Location:2307
      DAO; FAD dependent oxidoreductase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      108854786..108875798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371307.1XP_054227282.1  D-amino-acid oxidase isoform X1

      UniProtKB/Swiss-Prot
      B2R7I5, P14920, Q16758, Q8N6R2
      UniProtKB/TrEMBL
      A0A024RBI1, Q7Z312
    2. XM_054371308.1XP_054227283.1  D-amino-acid oxidase isoform X2

      UniProtKB/TrEMBL
      Q7Z312