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    LDHAL6A lactate dehydrogenase A like 6A [ Homo sapiens (human) ]

    Gene ID: 160287, updated on 5-May-2024

    Summary

    Official Symbol
    LDHAL6Aprovided by HGNC
    Official Full Name
    lactate dehydrogenase A like 6Aprovided by HGNC
    Primary source
    HGNC:HGNC:28335
    See related
    Ensembl:ENSG00000166800 MIM:618928; AllianceGenome:HGNC:28335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LDH6A
    Summary
    Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in carbohydrate metabolic process and carboxylic acid metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 3.4) and thyroid (RPKM 0.2) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LDHAL6A in Genome Data Viewer
    Location:
    11p15.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18455856..18479601)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18553931..18577621)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18477403..18501148)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:18416070-18416735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3191 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:18417470-18417971 Neighboring gene lactate dehydrogenase A Neighboring gene lactate dehydrogenase C Neighboring gene ReSE screen-validated silencer GRCh37_chr11:18507685-18507894 Neighboring gene tumor susceptibility 101 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4502 Neighboring gene UEV and lactate/malate dehyrogenase domains Neighboring gene ReSE screen-validated silencer GRCh37_chr11:18600575-18600756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4505 Neighboring gene Sharpr-MPRA regulatory region 13786

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC23940

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-lactate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in lactate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    L-lactate dehydrogenase A-like 6A
    Names
    LDHA-like protein 6A
    NP_001137543.1
    NP_659409.2
    XP_005252862.2
    XP_011518224.2
    XP_011518225.1
    XP_011518226.1
    XP_011518227.1
    XP_054223838.1
    XP_054223839.1
    XP_054223840.1
    XP_054223841.1
    XP_054223842.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144071.2NP_001137543.1  L-lactate dehydrogenase A-like 6A

      See identical proteins and their annotated locations for NP_001137543.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AC027544, AY581313
      Consensus CDS
      CCDS7841.1
      UniProtKB/Swiss-Prot
      D3DQY5, Q6ZMR3
      Related
      ENSP00000379516.3, ENST00000396213.7
      Conserved Domains (1) summary
      cd05293
      Location:19329
      LDH_1; A subgroup of L-lactate dehydrogenases
    2. NM_144972.5NP_659409.2  L-lactate dehydrogenase A-like 6A

      See identical proteins and their annotated locations for NP_659409.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC027544, AY581313
      Consensus CDS
      CCDS7841.1
      UniProtKB/Swiss-Prot
      D3DQY5, Q6ZMR3
      Related
      ENSP00000280706.2, ENST00000280706.3
      Conserved Domains (1) summary
      cd05293
      Location:19329
      LDH_1; A subgroup of L-lactate dehydrogenases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      18455856..18479601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519923.3XP_011518225.1  L-lactate dehydrogenase A-like 6A isoform X3

      See identical proteins and their annotated locations for XP_011518225.1

      Conserved Domains (2) summary
      cd05293
      Location:19347
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:25343
      L-LDH-NAD; L-lactate dehydrogenase
    2. XM_011519922.3XP_011518224.2  L-lactate dehydrogenase A-like 6A isoform X1

    3. XM_005252805.5XP_005252862.2  L-lactate dehydrogenase A-like 6A isoform X2

      Conserved Domains (2) summary
      cd05293
      Location:43353
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:49349
      L-LDH-NAD; L-lactate dehydrogenase
    4. XM_011519925.2XP_011518227.1  L-lactate dehydrogenase A-like 6A isoform X3

      See identical proteins and their annotated locations for XP_011518227.1

      Conserved Domains (2) summary
      cd05293
      Location:19347
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:25343
      L-LDH-NAD; L-lactate dehydrogenase
    5. XM_011519924.3XP_011518226.1  L-lactate dehydrogenase A-like 6A isoform X3

      See identical proteins and their annotated locations for XP_011518226.1

      Conserved Domains (2) summary
      cd05293
      Location:19347
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:25343
      L-LDH-NAD; L-lactate dehydrogenase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      18553931..18577621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367865.1XP_054223840.1  L-lactate dehydrogenase A-like 6A isoform X3

    2. XM_054367863.1XP_054223838.1  L-lactate dehydrogenase A-like 6A isoform X1

    3. XM_054367864.1XP_054223839.1  L-lactate dehydrogenase A-like 6A isoform X2

    4. XM_054367867.1XP_054223842.1  L-lactate dehydrogenase A-like 6A isoform X3

    5. XM_054367866.1XP_054223841.1  L-lactate dehydrogenase A-like 6A isoform X3