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    Igf2r insulin-like growth factor 2 receptor [ Mus musculus (house mouse) ]

    Gene ID: 16004, updated on 10-Aug-2021

    Summary

    Official Symbol
    Igf2rprovided by MGI
    Official Full Name
    insulin-like growth factor 2 receptorprovided by MGI
    Primary source
    MGI:MGI:96435
    See related
    Ensembl:ENSMUSG00000023830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CI-; Mpr3; CD222; CI-MPR; M6P/IG; Mpr300; AI661837; M6P/IGF2R
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 34.0), placenta adult (RPKM 24.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Igf2r in Genome Data Viewer
    Location:
    17 A1; 17 8.64 cM
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (12901293..12988593, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12682406..12769706, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (12875272..12962572, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 2 Neighboring gene solute carrier family 22 (organic cation transporter), member 1 Neighboring gene antisense Igf2r RNA Neighboring gene VISTA enhancer mm89 Neighboring gene predicted gene, 49958

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin-like growth factor II binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin-like growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables insulin-like growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mannose binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinoic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables retromer complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in liver development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysosomal transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation by host of viral process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    part_of clathrin coat ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    cation-independent mannose-6-phosphate receptor
    Names
    300 kDa mannose 6-phosphate receptor
    CI Man-6-P receptor
    IGF-II receptor
    IGF-II/CI-MPR
    M6P/IGF2 receptor
    M6PR
    MPR 300
    cation-independent MPR
    insulin-like growth factor II receptor
    mannose-6-phosphate receptor, cation independent

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010515.2NP_034645.2  cation-independent mannose-6-phosphate receptor precursor

      See identical proteins and their annotated locations for NP_034645.2

      Status: VALIDATED

      Source sequence(s)
      AC116804, AC167817, AK053045, BB865604, BP757292, BQ900123, CA324933, CD545656, CF167933, CK639250, CN461279, CN530622
      Consensus CDS
      CCDS37436.1
      UniProtKB/Swiss-Prot
      Q07113
      UniProtKB/TrEMBL
      Q8C6V9
      Related
      ENSMUSP00000024599.8, ENSMUST00000024599.14
      Conserved Domains (3) summary
      cd00062
      Location:18901935
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      pfam00878
      Location:10241171
      CIMR; Cation-independent mannose-6-phosphate receptor repeat
      pfam09451
      Location:335467
      ATG27; Autophagy-related protein 27

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      12901293..12988593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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