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    Ica1 islet cell autoantigen 1 [ Mus musculus (house mouse) ]

    Gene ID: 15893, updated on 3-Oct-2018

    Summary

    Official Symbol
    Ica1provided by MGI
    Official Full Name
    islet cell autoantigen 1provided by MGI
    Primary source
    MGI:MGI:96391
    See related
    Ensembl:ENSMUSG00000062995 Vega:OTTMUSG00000023181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    69kDa; ICA69
    Expression
    Broad expression in testis adult (RPKM 6.7), cortex adult (RPKM 5.0) and 19 other tissues See more
    Orthologs

    Genomic context

    See Ica1 in Genome Data Viewer
    Location:
    6 A1; 6 4.38 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (8630527..8778535, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (8580527..8728484, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene glucocorticoid induced transcript 1 Neighboring gene F-box protein 5 Neighboring gene predicted gene, 35621 Neighboring gene predicted gene, 38765 Neighboring gene predicted gene, 35674

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi stack ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    islet cell autoantigen 1
    Names
    69 kDa islet cell autoantigen
    ICAp69
    ica1
    islet cell autoantigen 1, 69 kDa
    islet cell autoantigen p69
    p69

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252266.1NP_001239195.1  islet cell autoantigen 1 isoform 2

      See identical proteins and their annotated locations for NP_001239195.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK005965, CB056959, CD775505
      UniProtKB/Swiss-Prot
      P97411
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260457
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    2. NM_010492.3NP_034622.3  islet cell autoantigen 1 isoform 1

      See identical proteins and their annotated locations for NP_034622.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      BQ442697, CF914747, CO044997, DV658174, DV659030
      Consensus CDS
      CCDS19911.1
      UniProtKB/Swiss-Prot
      P97411
      Related
      ENSMUSP00000040062.5, OTTMUSP00000026900, ENSMUST00000038403.11, OTTMUST00000056068
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260478
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      8630527..8778535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504993.3XP_006505056.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006505056.1

      UniProtKB/Swiss-Prot
      P97411
      Related
      ENSMUSP00000111182.1, OTTMUSP00000026902, ENSMUST00000115520.7, OTTMUST00000056071
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260478
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    2. XM_006504995.3XP_006505058.1  islet cell autoantigen 1 isoform X2

      See identical proteins and their annotated locations for XP_006505058.1

      UniProtKB/Swiss-Prot
      P97411
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260457
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    3. XM_006504994.3XP_006505057.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006505057.1

      UniProtKB/Swiss-Prot
      P97411
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260478
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    4. XM_017321405.1XP_017176894.1  islet cell autoantigen 1 isoform X3

    RNA

    1. XR_001785099.1 RNA Sequence

    2. XR_001785098.1 RNA Sequence

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