U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ica1 islet cell autoantigen 1 [ Mus musculus (house mouse) ]

    Gene ID: 15893, updated on 26-Sep-2022

    Summary

    Official Symbol
    Ica1provided by MGI
    Official Full Name
    islet cell autoantigen 1provided by MGI
    Primary source
    MGI:MGI:96391
    See related
    Ensembl:ENSMUSG00000062995 AllianceGenome:MGI:96391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    69kDa; ICA69
    Summary
    Predicted to enable membrane curvature sensor activity and protein domain specific binding activity. Predicted to be involved in regulation of protein-containing complex assembly and regulation of transport. Predicted to act upstream of or within neurotransmitter transport. Located in cytosol and synaptic vesicle membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and trigeminal nerve. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ICA1 (islet cell autoantigen 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 6.7), cortex adult (RPKM 5.0) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ica1 in Genome Data Viewer
    Location:
    6 A1; 6 4.38 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (8630527..8778540, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (8630527..8778540, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene glucocorticoid induced transcript 1 Neighboring gene F-box protein 5 Neighboring gene predicted gene, 35621 Neighboring gene predicted gene, 53310 Neighboring gene predicted gene, 53311 Neighboring gene predicted gene, 38765 Neighboring gene predicted gene, 35674

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables membrane curvature sensor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    islet cell autoantigen 1
    Names
    69 kDa islet cell autoantigen
    ICAp69
    islet cell autoantigen 1, 69 kDa
    islet cell autoantigen p69
    p69

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252266.2NP_001239195.1  islet cell autoantigen 1 isoform 2

      See identical proteins and their annotated locations for NP_001239195.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2, 5, and 6 all encode the same isoform (2).
      Source sequence(s)
      AC158670
      UniProtKB/Swiss-Prot
      P97411
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261457
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    2. NM_001410043.1NP_001396972.1  islet cell autoantigen 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158670
    3. NM_001410044.1NP_001396973.1  islet cell autoantigen 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158670
    4. NM_001410045.1NP_001396974.1  islet cell autoantigen 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158670
    5. NM_001410046.1NP_001396975.1  islet cell autoantigen 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158670
    6. NM_001410047.1NP_001396976.1  islet cell autoantigen 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158670
    7. NM_001410048.1NP_001396977.1  islet cell autoantigen 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158670
    8. NM_001410049.1NP_001396978.1  islet cell autoantigen 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC158670
    9. NM_001410050.1NP_001396979.1  islet cell autoantigen 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC158670
    10. NM_010492.4NP_034622.3  islet cell autoantigen 1 isoform 1

      See identical proteins and their annotated locations for NP_034622.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AC158670
      Consensus CDS
      CCDS19911.1
      UniProtKB/Swiss-Prot
      P97411, Q9R2C4
      Related
      ENSMUSP00000040062.6, ENSMUST00000038403.12
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260478
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      8630527..8778540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255193.1XP_030111053.1  islet cell autoantigen 1 isoform X2

      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261457
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    2. XM_006504993.4XP_006505056.1  islet cell autoantigen 1 isoform X1

      UniProtKB/Swiss-Prot
      P97411, Q9R2C4
      Related
      ENSMUSP00000111182.2, ENSMUST00000115520.8
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260478
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    3. XM_006504995.5XP_006505058.1  islet cell autoantigen 1 isoform X2

      UniProtKB/Swiss-Prot
      P97411
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261457
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    4. XM_036165881.1XP_036021774.1  islet cell autoantigen 1 isoform X2

      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:261457
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    5. XM_006504994.5XP_006505057.1  islet cell autoantigen 1 isoform X1

      UniProtKB/Swiss-Prot
      P97411, Q9R2C4
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260478
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    6. XM_017321405.1XP_017176894.1  islet cell autoantigen 1 isoform X3

      Conserved Domains (1) summary
      pfam04629
      Location:82294
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    RNA

    1. XR_003956165.2 RNA Sequence

    2. XR_001785099.3 RNA Sequence

    3. XR_001785098.3 RNA Sequence