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    CXorf65 chromosome X open reading frame 65 [ Homo sapiens (human) ]

    Gene ID: 158830, updated on 17-Jun-2024

    Summary

    Official Symbol
    CXorf65provided by HGNC
    Official Full Name
    chromosome X open reading frame 65provided by HGNC
    Primary source
    HGNC:HGNC:33713
    See related
    Ensembl:ENSG00000204165 AllianceGenome:HGNC:33713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in testis (RPKM 7.7), lymph node (RPKM 2.7) and 5 other tissues See more
    Orthologs
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    Genomic context

    See CXorf65 in Genome Data Viewer
    Location:
    Xq13.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (71103889..71106740, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (69537985..69540832, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70323739..70326590, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene sorting nexin 12 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:70288147-70288340 Neighboring gene Sharpr-MPRA regulatory region 4327 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:70320272-70320882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29736 Neighboring gene forkhead box O4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:70330888-70332087 Neighboring gene interleukin 2 receptor subunit gamma Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:70342400-70343599 Neighboring gene mediator complex subunit 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General protein information

    Preferred Names
    uncharacterized protein CXorf65

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021141.1 RefSeqGene

      Range
      5049..7900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025265.3NP_001020436.1  uncharacterized protein CXorf65

      See identical proteins and their annotated locations for NP_001020436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AL590764, DB457782, DB523273
      Consensus CDS
      CCDS35324.1
      UniProtKB/Swiss-Prot
      A6NEN9
      Related
      ENSP00000363369.4, ENST00000374251.6
      Conserved Domains (1) summary
      pfam15874
      Location:2102
      Il2rg; Putative Interleukin 2 receptor, gamma chain

    RNA

    1. NR_033212.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in a 5' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL590764, BC144434
      Related
      ENST00000438526.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      71103889..71106740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262244.5XP_005262301.1  uncharacterized protein CXorf65 isoform X1

      Conserved Domains (1) summary
      pfam15874
      Location:283
      Il2rg; Putative Interleukin 2 receptor, gamma chain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      69537985..69540832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326546.1XP_054182521.1  uncharacterized protein CXorf65 isoform X1