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    ARHGAP36 Rho GTPase activating protein 36 [ Homo sapiens (human) ]

    Gene ID: 158763, updated on 8-Jul-2021

    Summary

    Official Symbol
    ARHGAP36provided by HGNC
    Official Full Name
    Rho GTPase activating protein 36provided by HGNC
    Primary source
    HGNC:HGNC:26388
    See related
    Ensembl:ENSG00000147256 MIM:300937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Restricted expression toward adrenal (RPKM 54.0) See more
    Orthologs
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    Genomic context

    See ARHGAP36 in Genome Data Viewer
    Location:
    Xq26.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (131058346..131089885)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (130192320..130223859)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ecto-NOX disulfide-thiol exchanger 2 Neighboring gene uncharacterized LOC105373338 Neighboring gene long intergenic non-protein coding RNA 1201 Neighboring gene RNA, 7SL, cytoplasmic 191, pseudogene Neighboring gene olfactory receptor family 11 subfamily Q member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ30058

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 36

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282607.2NP_001269536.1  rho GTPase-activating protein 36 isoform 2

      See identical proteins and their annotated locations for NP_001269536.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region whihc results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AA405456, AK296748, AL590131
      Consensus CDS
      CCDS65320.1
      UniProtKB/Swiss-Prot
      Q6ZRI8
      Related
      ENSP00000359960.1, ENST00000370922.5
      Conserved Domains (1) summary
      cd04376
      Location:215420
      RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...
    2. NM_001330651.1NP_001317580.1  rho GTPase-activating protein 36 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL590131
      Consensus CDS
      CCDS83489.1
      UniProtKB/Swiss-Prot
      Q6ZRI8
      Related
      ENSP00000359959.1, ENST00000370921.1
      Conserved Domains (1) summary
      cd04376
      Location:91296
      RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...
    3. NM_144967.4NP_659404.2  rho GTPase-activating protein 36 isoform 1 precursor

      See identical proteins and their annotated locations for NP_659404.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK128203, AL590131, BC063790, CD107623
      Consensus CDS
      CCDS14628.1
      UniProtKB/Swiss-Prot
      Q6ZRI8
      Related
      ENSP00000276211.5, ENST00000276211.10
      Conserved Domains (1) summary
      cd04376
      Location:227432
      RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      131058346..131089885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531280.1XP_011529582.1  rho GTPase-activating protein 36 isoform X1

      See identical proteins and their annotated locations for XP_011529582.1

      UniProtKB/Swiss-Prot
      Q6ZRI8
      Conserved Domains (1) summary
      cd04376
      Location:91296
      RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...
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