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    RDH10 retinol dehydrogenase 10 [ Homo sapiens (human) ]

    Gene ID: 157506, updated on 11-Apr-2024

    Summary

    Official Symbol
    RDH10provided by HGNC
    Official Full Name
    retinol dehydrogenase 10provided by HGNC
    Primary source
    HGNC:HGNC:19975
    See related
    Ensembl:ENSG00000121039 MIM:607599; AllianceGenome:HGNC:19975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SDR16C4
    Summary
    This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. [provided by RefSeq, Dec 2011]
    Expression
    Ubiquitous expression in kidney (RPKM 18.4), gall bladder (RPKM 13.9) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RDH10 in Genome Data Viewer
    Location:
    8q21.11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (73294602..73325281)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (73724122..73754883)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (74206837..74237516)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chromosome 8 open reading frame 89 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74197691-74198192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74198193-74198692 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74205120-74205828 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74205829-74206536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74211031-74211531 Neighboring gene peroxiredoxin like 2A pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr8:74216479-74216980 Neighboring gene RDH10 antisense RNA 1 Neighboring gene ribosomal protein L7 Neighboring gene uncharacterized LOC105375899 Neighboring gene STAU2 antisense RNA 1 Neighboring gene staufen double-stranded RNA binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in bud elongation involved in lung branching IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ear development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic camera-type eye development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic forelimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic viscerocranium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephros development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural crest cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nose development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of retinoic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in primary lung bud formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retinal metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retinoic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retinoid metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in retinol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within visual perception IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    retinol dehydrogenase 10
    Names
    retinol dehydrogenase 10 (all-trans)
    short chain dehydrogenase/reductase family 16C member 4
    NP_742034.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172037.5NP_742034.1  retinol dehydrogenase 10

      See identical proteins and their annotated locations for NP_742034.1

      Status: REVIEWED

      Source sequence(s)
      AC111149, AF456765, BC067131, BM472905, BM804062, BM979260, CD110145
      Consensus CDS
      CCDS6213.1
      UniProtKB/Swiss-Prot
      Q8IZV5
      Related
      ENSP00000240285.5, ENST00000240285.10
      Conserved Domains (1) summary
      cd05339
      Location:38307
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      73294602..73325281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      73724122..73754883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)