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    CYP2J2 cytochrome P450 family 2 subfamily J member 2 [ Homo sapiens (human) ]

    Gene ID: 1573, updated on 17-Jun-2024

    Summary

    Official Symbol
    CYP2J2provided by HGNC
    Official Full Name
    cytochrome P450 family 2 subfamily J member 2provided by HGNC
    Primary source
    HGNC:HGNC:2634
    See related
    Ensembl:ENSG00000134716 MIM:601258; AllianceGenome:HGNC:2634
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPJ2; CYPIIJ2
    Summary
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in small intestine (RPKM 44.5), heart (RPKM 35.2) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CYP2J2 in Genome Data Viewer
    Location:
    1p32.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (59893308..59969212, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (59771763..59847665, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (60358980..60392445, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378758 Neighboring gene uncharacterized LOC101926944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 943 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:60280925-60281488 Neighboring gene hook microtubule tethering protein 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:60380537-60381736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:60391793-60392328 Neighboring gene RNA, 7SL, cytoplasmic 475, pseudogene Neighboring gene chromosome 1 open reading frame 87 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:60505410-60506609

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epoxygenase P450 pathway TAS
    Traceable Author Statement
    more info
     
    involved_in fatty acid metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in icosanoid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in linoleic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of heart contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cytochrome P450 2J2
    Names
    albendazole monooxygenase (hydroxylating)
    albendazole monooxygenase (sulfoxide-forming)
    arachidonic acid epoxygenase
    cytochrome P450, family 2, subfamily J, polypeptide 2
    cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2
    flavoprotein-linked monooxygenase
    hydroperoxy icosatetraenoate isomerase
    microsomal monooxygenase
    NP_000766.2
    XP_047303454.1
    XP_047303455.1
    XP_054190678.1
    XP_054190679.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007931.2 RefSeqGene

      Range
      47439..80904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000775.4NP_000766.2  cytochrome P450 2J2

      See identical proteins and their annotated locations for NP_000766.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the protein-coding transcript.
      Source sequence(s)
      BC032594
      Consensus CDS
      CCDS613.1
      UniProtKB/Swiss-Prot
      B2RD33, P51589, Q8TF13
      Related
      ENSP00000360247.3, ENST00000371204.4
      Conserved Domains (1) summary
      pfam00067
      Location:44497
      p450; Cytochrome P450

    RNA

    1. NR_134981.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC032594, CD013972
      Related
      ENST00000466095.5
    2. NR_134982.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC113175, BC032594, CD013973
      Related
      ENST00000468257.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      59893308..59969212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447499.1XP_047303455.1  cytochrome P450 2J2 isoform X1

    2. XM_047447498.1XP_047303454.1  cytochrome P450 2J2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      59771763..59847665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334704.1XP_054190679.1  cytochrome P450 2J2 isoform X1

    2. XM_054334703.1XP_054190678.1  cytochrome P450 2J2 isoform X1