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    Htr1b 5-hydroxytryptamine (serotonin) receptor 1B [ Mus musculus (house mouse) ]

    Gene ID: 15551, updated on 12-May-2024

    Summary

    Official Symbol
    Htr1bprovided by MGI
    Official Full Name
    5-hydroxytryptamine (serotonin) receptor 1Bprovided by MGI
    Primary source
    MGI:MGI:96274
    See related
    Ensembl:ENSMUSG00000049511 AllianceGenome:MGI:96274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5-HT-1B
    Summary
    Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in several processes, including cellular response to temperature stimulus; negative regulation of serotonin secretion; and protein kinase C-activating G protein-coupled receptor signaling pathway. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; bone remodeling; and response to toxic substance. Located in cytoplasm; plasma membrane; and serotonergic synapse. Is integral component of presynaptic membrane. Part of G protein-coupled serotonin receptor complex. Is expressed in several structures, including alimentary system; central nervous system; eye; gonad; and immune system. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and conduct disorder. Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See Htr1b in Genome Data Viewer
    Location:
    9 E1; 9 44.61 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (81510344..81515885, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (81628291..81633832, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24762 Neighboring gene predicted gene, 39381 Neighboring gene high-mobility group nucleosome binding domain 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24763 Neighboring gene STARR-seq mESC enhancer starr_24764 Neighboring gene STARR-seq mESC enhancer starr_24766 Neighboring gene RIKEN cDNA D430036J16 gene Neighboring gene STARR-seq mESC enhancer starr_24767 Neighboring gene STARR-seq mESC enhancer starr_24768 Neighboring gene predicted gene, 53506 Neighboring gene SET nuclear oncogene pseudogene Neighboring gene STARR-seq mESC enhancer starr_24769 Neighboring gene STARR-seq mESC enhancer starr_24770 Neighboring gene STARR-seq mESC enhancer starr_24771 Neighboring gene meiotic double-stranded break formation protein 4 Neighboring gene STARR-seq mESC enhancer starr_24772 Neighboring gene STARR-seq mESC enhancer starr_24773 Neighboring gene STARR-seq mESC enhancer starr_24774 Neighboring gene STARR-seq mESC enhancer starr_24775 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • D430036J16Rik

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in G protein-coupled receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within behavior IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within bone remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to alkaloid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to temperature stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in drinking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gamma-aminobutyric acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of serotonin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to toxic substance IDA
    Inferred from Direct Assay
    more info
     
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of G protein-coupled serotonin receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in calyx of Held ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in serotonergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 1B
    Names
    5-HT1B receptor
    5-HT<1B> receptor
    serotonin receptor 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410237.1NP_001397166.1  5-hydroxytryptamine receptor 1B

      Status: VALIDATED

      Source sequence(s)
      AC158998
      UniProtKB/Swiss-Prot
      P28334
      UniProtKB/TrEMBL
      Q0VES5
    2. NM_010482.2NP_034612.1  5-hydroxytryptamine receptor 1B

      See identical proteins and their annotated locations for NP_034612.1

      Status: VALIDATED

      Source sequence(s)
      AC158998
      Consensus CDS
      CCDS23370.1
      UniProtKB/Swiss-Prot
      P28334
      UniProtKB/TrEMBL
      Q0VES5
      Related
      ENSMUSP00000139389.2, ENSMUST00000183482.2
      Conserved Domains (1) summary
      cd15333
      Location:42376
      7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      81510344..81515885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)