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    Hspa4 heat shock protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 15525, updated on 5-Aug-2018

    Summary

    Official Symbol
    Hspa4provided by MGI
    Official Full Name
    heat shock protein 4provided by MGI
    Primary source
    MGI:MGI:1342292
    See related
    Ensembl:ENSMUSG00000020361 Vega:OTTMUSG00000000056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    70kDa; APG-2; Hsp110; Hsp70RY; AI317151; mKIAA4025
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 44.3), adrenal adult (RPKM 30.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hspa4 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.91 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (53259814..53300479, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (53073316..53113981, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene follistatin-like 4 Neighboring gene predicted gene 11186 Neighboring gene TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene predicted gene, 30525 Neighboring gene zinc finger, CCHC domain containing 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4025

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heat shock 70 kDa protein 4
    Names
    heat shock 70-related protein APG-2
    heat shock protein, 110 kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008300.3NP_032326.3  heat shock 70 kDa protein 4

      See identical proteins and their annotated locations for NP_032326.3

      Status: VALIDATED

      Source sequence(s)
      AA203833, AI316935, AL596382, AW545353, CA316420, CF741432, CN458707
      Consensus CDS
      CCDS24674.1
      UniProtKB/TrEMBL
      Q3U2G2
      Related
      ENSMUSP00000020630.7, OTTMUSP00000000078, ENSMUST00000020630.7, OTTMUST00000000145
      Conserved Domains (2) summary
      cd11737
      Location:2384
      HSPA4_NBD; Nucleotide-binding domain of HSPA4
      pfam00012
      Location:3609
      HSP70; Hsp70 protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      53259814..53300479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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