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    Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 [ Mus musculus (house mouse) ]

    Gene ID: 15519, updated on 8-Jul-2021

    Summary

    Official Symbol
    Hsp90aa1provided by MGI
    Official Full Name
    heat shock protein 90, alpha (cytosolic), class A member 1provided by MGI
    Primary source
    MGI:MGI:96250
    See related
    Ensembl:ENSMUSG00000021270
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hs; Hsp; hsp4; 86kDa; 89kDa; Hsp89; Hsp90; Hspca; Hsp86-1; AL024080; AL024147
    Expression
    Broad expression in placenta adult (RPKM 235.9), CNS E11.5 (RPKM 213.3) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hsp90aa1 in Genome Data Viewer
    Location:
    12 F1; 12 60.75 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110657470..110662829, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110691036..110696395, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (111929246..111934605, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700001K19 gene Neighboring gene predicted gene, 53768 Neighboring gene WD repeat domain 20 Neighboring gene MOK protein kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Gene trapped (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TPR domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables disordered domain specific binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nitric-oxide synthase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nitric-oxide synthase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables unfolded protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nitric oxide biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytotoxic T cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tau-protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein insertion into mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein refolding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to unfolded protein TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in telomerase holoenzyme complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in dendritic growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    is_active_in myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heat shock protein HSP 90-alpha
    Names
    HSP 86
    HSP86
    TSTA
    heat shock 86 kDa
    heat shock protein 1, alpha
    heat shock protein 90kDa alpha (cytosolic), class A member 1
    heat shock protein, 1
    heat shock protein, 86 kDa 1
    heat shock protein, 89 kDa
    tumor-specific transplantation 86 kDa antigen
    NP_034610.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010480.5NP_034610.1  heat shock protein HSP 90-alpha

      See identical proteins and their annotated locations for NP_034610.1

      Status: PROVISIONAL

      Source sequence(s)
      AC152827, AL596265
      Consensus CDS
      CCDS26172.1
      UniProtKB/Swiss-Prot
      P07901
      UniProtKB/TrEMBL
      Q80Y52
      Related
      ENSMUSP00000091921.5, ENSMUST00000094361.11
      Conserved Domains (3) summary
      smart00387
      Location:40191
      HATPase_c; Histidine kinase-like ATPases
      PTZ00272
      Location:18733
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:196723
      HSP90; Hsp90 protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      110657470..110662829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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