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    Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 [ Mus musculus (house mouse) ]

    Gene ID: 15516, updated on 5-Sep-2021

    Summary

    Official Symbol
    Hsp90ab1provided by MGI
    Official Full Name
    heat shock protein 90 alpha (cytosolic), class B member 1provided by MGI
    Primary source
    MGI:MGI:96247
    See related
    Ensembl:ENSMUSG00000023944
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hsp; 90kDa; Hsp84; Hsp90; Hspcb; C81438; Hsp84-1; AL022974
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 511.2), placenta adult (RPKM 332.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hsp90ab1 in Genome Data Viewer
    Location:
    17 B3; 17 22.59 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45878704..45884187, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45567778..45573261, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (45704727..45710210, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon Neighboring gene solute carrier family 35, member B2 Neighboring gene predicted gene, 35399 Neighboring gene solute carrier family 29 (nucleoside transporters), member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC115780

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables CTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables UTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables disordered domain specific binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heterocyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone methyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein folding chaperone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to protein kinase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sulfonylurea receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tau protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to interleukin-4 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in central nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of complement-dependent cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transforming growth factor beta activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cyclin-dependent protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cyclin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in supramolecular fiber organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomerase holoenzyme complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in virion attachment to host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of HSP90-CDC37 chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of HSP90-CDC37 chaperone complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of aryl hydrocarbon receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ooplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm head plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heat shock protein HSP 90-beta
    Names
    HSP 84
    TSTA
    heat shock 84 kDa
    heat shock 90kDa protein 1, beta
    heat shock protein 1, beta
    heat shock protein 90kDa alpha (cytosolic), class B member 1
    heat shock protein, 84 kDa 1
    retinal degeneration slow protein
    tumor-specific transplantation 84 kDa antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008302.3NP_032328.2  heat shock protein HSP 90-beta

      See identical proteins and their annotated locations for NP_032328.2

      Status: PROVISIONAL

      Source sequence(s)
      AC163677
      Consensus CDS
      CCDS28812.1
      UniProtKB/Swiss-Prot
      P11499
      UniProtKB/TrEMBL
      Q71LX8
      Related
      ENSMUSP00000024739.8, ENSMUST00000024739.14
      Conserved Domains (1) summary
      cl27733
      Location:14724
      HSP90; Hsp90 protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      45878704..45884187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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