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    Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 [ Mus musculus (house mouse) ]

    Gene ID: 15516, updated on 3-Oct-2018

    Summary

    Official Symbol
    Hsp90ab1provided by MGI
    Official Full Name
    heat shock protein 90 alpha (cytosolic), class B member 1provided by MGI
    Primary source
    MGI:MGI:96247
    See related
    Ensembl:ENSMUSG00000023944 Vega:OTTMUSG00000020123
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    90kDa; Hsp84; Hsp90; Hspcb; C81438; Hsp84-1; AL022974
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 511.2), placenta adult (RPKM 332.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hsp90ab1 in Genome Data Viewer
    Location:
    17 B3; 17 22.59 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (45567778..45573261, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (45704727..45710210, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon Neighboring gene solute carrier family 35, member B2 Neighboring gene predicted gene, 35399 Neighboring gene solute carrier family 29 (nucleoside transporters), member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC115780

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    CTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    UTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    dATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone methyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to protein kinase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sulfonylurea receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    tau protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to interleukin-4 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    central nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of complement-dependent cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transforming growth factor beta activation ISO
    Inferred from Sequence Orthology
    more info
     
    placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cyclin-dependent protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cyclin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cellular protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cellular protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    supramolecular fiber organization ISO
    Inferred from Sequence Orthology
    more info
     
    telomerase holoenzyme complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    virion attachment to host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    HSP90-CDC37 chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    HSP90-CDC37 chaperone complex ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    aryl hydrocarbon receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ooplasm ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    sperm head plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heat shock protein HSP 90-beta
    Names
    HSP 84
    TSTA
    heat shock 84 kDa
    heat shock 90kDa protein 1, beta
    heat shock protein 1, beta
    heat shock protein 90kDa alpha (cytosolic), class B member 1
    heat shock protein, 84 kDa 1
    retinal degeneration slow protein
    tumor-specific transplantation 84 kDa antigen

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008302.3NP_032328.2  heat shock protein HSP 90-beta

      See identical proteins and their annotated locations for NP_032328.2

      Status: PROVISIONAL

      Source sequence(s)
      AC163677
      Consensus CDS
      CCDS28812.1
      UniProtKB/Swiss-Prot
      P11499
      UniProtKB/TrEMBL
      Q71LX8
      Related
      ENSMUSP00000024739.7, OTTMUSP00000021764, ENSMUST00000024739.13, OTTMUST00000047842
      Conserved Domains (1) summary
      cl27733
      Location:14724
      HSP90; Hsp90 protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      45567778..45573261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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