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    Hspa2 heat shock protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 15512, updated on 31-Jan-2019

    Summary

    Official Symbol
    Hspa2provided by MGI
    Official Full Name
    heat shock protein 2provided by MGI
    Primary source
    MGI:MGI:96243
    See related
    Ensembl:ENSMUSG00000059970
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    70kDa; HSP70.2; HSP70A2; Hsp70-2
    Expression
    Biased expression in testis adult (RPKM 333.5), bladder adult (RPKM 20.6) and 1 other tissue See more
    Orthologs

    Genomic context

    See Hspa2 in Genome Data Viewer
    Location:
    12 C3; 12 33.73 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (76403854..76406938)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (77505163..77507925)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene RIKEN cDNA 4930426I24 gene Neighboring gene protein phosphatase 1, regulatory subunit 36 Neighboring gene predicted gene 10451

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Antigen processing and presentation, organism-specific biosystem (from KEGG)
      Antigen processing and presentation, organism-specific biosystem
      Antigen processing and presentation
    • Antigen processing and presentation, conserved biosystem (from KEGG)
      Antigen processing and presentation, conserved biosystem
      Antigen processing and presentation
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Estrogen signaling pathway, organism-specific biosystem (from KEGG)
      Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
    • Estrogen signaling pathway, conserved biosystem (from KEGG)
      Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
      Longevity regulating pathway - multiple species, organism-specific biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
      Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Meiosis, organism-specific biosystem (from REACTOME)
      Meiosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Meiotic Synapsis, organism-specific biosystem (from REACTOME)
      Meiotic Synapsis, organism-specific biosystemMeiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form a...
    • Meiotic synapsis, organism-specific biosystem (from REACTOME)
      Meiotic synapsis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Mus musculus biological processes, organism-specific biosystem (from REACTOME)
      Mus musculus biological processes, organism-specific biosystemCertain mouse pathways have been fully manually curated in Reactome in order to support the manual inference of well-conserved but less well-studied human pathways. These pathways include Circadian...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, 35S U5-snRNP, organism-specific biosystem (from KEGG)
      Spliceosome, 35S U5-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Spliceosome, 35S U5-snRNP, conserved biosystem (from KEGG)
      Spliceosome, 35S U5-snRNP, conserved biosystemStructural complex; Genetic information processing; Spliceosome
    • Spliceosome, Prp19/CDC5L complex, organism-specific biosystem (from KEGG)
      Spliceosome, Prp19/CDC5L complex, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Spliceosome, Prp19/CDC5L complex, conserved biosystem (from KEGG)
      Spliceosome, Prp19/CDC5L complex, conserved biosystemStructural complex; Genetic information processing; Spliceosome
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7795, MGC58299

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity, coupled IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    glycolipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding involved in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to unfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ATPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of calcium-transporting ATPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    response to unfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptonemal complex disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    CatSper complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    meiotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion HDA PubMed 
    myelin sheath HDA PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heat shock-related 70 kDa protein 2
    Names
    heat shock 70kDa protein 2
    heat shock protein 70.2
    heat shock protein, 70 kDa 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002012.1NP_001002012.1  heat shock-related 70 kDa protein 2

      See identical proteins and their annotated locations for NP_001002012.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence and encodes the same protein, as compared to variant 1.
      Source sequence(s)
      BC052350
      Consensus CDS
      CCDS25993.1
      UniProtKB/Swiss-Prot
      P17156
      Related
      ENSMUSP00000079306.5, ENSMUST00000080449.6
      Conserved Domains (1) summary
      cl26953
      Location:2615
      HSP70; Hsp70 protein
    2. NM_008301.4NP_032327.2  heat shock-related 70 kDa protein 2

      See identical proteins and their annotated locations for NP_032327.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK132261, BC052350, BY282370
      Consensus CDS
      CCDS25993.1
      UniProtKB/Swiss-Prot
      P17156
      Related
      ENSMUSP00000151408.1, ENSMUST00000219555.1
      Conserved Domains (1) summary
      cl26953
      Location:2615
      HSP70; Hsp70 protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      76403854..76406938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515484.3XP_006515547.1  heat shock-related 70 kDa protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006515547.1

      UniProtKB/Swiss-Prot
      P17156
      Conserved Domains (1) summary
      cl26953
      Location:2615
      HSP70; Hsp70 protein
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