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    Hsf1 heat shock factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 15499, updated on 6-Sep-2021

    Summary

    Official Symbol
    Hsf1provided by MGI
    Official Full Name
    heat shock factor 1provided by MGI
    Primary source
    MGI:MGI:96238
    See related
    Ensembl:ENSMUSG00000022556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HSTF; HSTF 1; AA960185; Hsf1beta; Hsf1alpha
    Expression
    Ubiquitous expression in ovary adult (RPKM 47.3), thymus adult (RPKM 42.2) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hsf1 in Genome Data Viewer
    Location:
    15 D3; 15 35.95 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76361562..76385355)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76477362..76501155)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (76307875..76331402)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat family member 1 Neighboring gene microRNA 6954 Neighboring gene block of proliferation 1 Neighboring gene scleraxis Neighboring gene diacylglycerol O-acyltransferase 1 Neighboring gene scratch family zinc finger 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables STAT family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein self-association ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific single stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation elongation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to angiotensin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to diamide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to sodium arsenite ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic process involved in female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic DNA fragmentation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription from RNA polymerase II promoter in response to heat stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of spindle checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to testosterone ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chaperone complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heat shock factor protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331152.1NP_001318081.1  heat shock factor protein 1 isoform gammaalpha

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (gammaalpha).
      Source sequence(s)
      AC157566, AK075651, BQ445304, BU925102, CB245398, CK622418
      UniProtKB/TrEMBL
      A0A075F6C2
    2. NM_001331153.1NP_001318082.1  heat shock factor protein 1 isoform gammabeta

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform gammabeta which is shorter compared to isoform gammaalpha.
      Source sequence(s)
      AC157566, AK075651, BQ445304, BU925102, CB245398
      Consensus CDS
      CCDS88785.1
      UniProtKB/TrEMBL
      A0A075F5C6
      Related
      ENSMUSP00000154638.2, ENSMUST00000228371.2
    3. NM_001331154.1NP_001318083.1  heat shock factor protein 1 isoform alpha

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform alpha which is shorter compared to isoform gammaalpha.
      Source sequence(s)
      AC157566, AK075651, BQ445304, BU925102, CB245398, CK622418
      Consensus CDS
      CCDS88787.1
      UniProtKB/Swiss-Prot
      P38532
      UniProtKB/TrEMBL
      A0A075F891
      Related
      ENSMUSP00000154602.2, ENSMUST00000227478.2
    4. NM_001331214.1NP_001318143.1  heat shock factor protein 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal exon and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 5, which has a shorter and distinct C-terminus, compared to isoform gammaalpha.
      Source sequence(s)
      AC157566, AK075651, BQ445304, BU925102, CB245398
      Consensus CDS
      CCDS88786.1
      UniProtKB/TrEMBL
      Q52L52
      Related
      ENSMUSP00000154328.2, ENSMUST00000226872.2
    5. NM_008296.3NP_032322.1  heat shock factor protein 1 isoform beta

      See identical proteins and their annotated locations for NP_032322.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform beta which is shorter compared to isoform gammaalpha.
      Source sequence(s)
      AC157566, AK075651, BQ445304, BU925102, CB245398
      Consensus CDS
      CCDS27572.1
      UniProtKB/Swiss-Prot
      P38532
      UniProtKB/TrEMBL
      A0A075F882
      Related
      ENSMUSP00000072617.6, ENSMUST00000072838.6
      Conserved Domains (2) summary
      smart00415
      Location:14118
      HSF; heat shock factor
      pfam06546
      Location:258503
      Vert_HS_TF; Vertebrate heat shock transcription factor

    RNA

    1. NR_138588.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate internal exons and retains an intron in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC157566, AK075651, AK089144, BG694608, BQ445304, BU925102, CB245398
      Related
      ENSMUST00000228868.2
    2. NR_138589.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks multiple alternate internal exons and uses an alternate splice site in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant gammaalpha, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC157566, AK075651, AK082507, BQ445304, BU925102, CB245398, CK622418

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76361562..76385355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159166.1XP_036015059.1  heat shock factor protein 1 isoform X2

      Conserved Domains (1) summary
      pfam06546
      Location:47314
      Vert_HS_TF; Vertebrate heat shock transcription factor
    2. XM_036159167.1XP_036015060.1  heat shock factor protein 1 isoform X3

      Conserved Domains (1) summary
      pfam06546
      Location:47292
      Vert_HS_TF; Vertebrate heat shock transcription factor
    3. XM_036159165.1XP_036015058.1  heat shock factor protein 1 isoform X2

      Conserved Domains (1) summary
      pfam06546
      Location:47314
      Vert_HS_TF; Vertebrate heat shock transcription factor
    4. XM_030248342.2XP_030104202.1  heat shock factor protein 1 isoform X3

      Conserved Domains (1) summary
      pfam06546
      Location:47292
      Vert_HS_TF; Vertebrate heat shock transcription factor
    5. XM_006520476.5XP_006520539.1  heat shock factor protein 1 isoform X3

      Conserved Domains (1) summary
      pfam06546
      Location:47292
      Vert_HS_TF; Vertebrate heat shock transcription factor
    6. XM_006520474.5XP_006520537.1  heat shock factor protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006520537.1

      Conserved Domains (1) summary
      pfam06546
      Location:47342
      Vert_HS_TF; Vertebrate heat shock transcription factor
    7. XM_006520475.5XP_006520538.1  heat shock factor protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006520538.1

      Conserved Domains (1) summary
      pfam06546
      Location:47342
      Vert_HS_TF; Vertebrate heat shock transcription factor
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