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    Oga O-GlcNAcase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 154968, updated on 18-Sep-2024

    Summary

    Symbol
    Ogaprovided by RGD
    Full Name
    O-GlcNAcaseprovided by RGD
    Primary source
    RGD:621077
    See related
    EnsemblRapid:ENSRNOG00000017822 AllianceGenome:RGD:621077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mgea5; Ncoat
    Summary
    Enables beta-N-acetylglucosaminidase activity and histone acetyltransferase activity. Involved in several processes, including positive regulation of mitochondrial depolarization; positive regulation of transport; and regulation of cellular protein metabolic process. Located in mitochondrion. Orthologous to human OGA (O-GlcNAcase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 586.9), Adrenal (RPKM 445.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Oga in Genome Data Viewer
    Location:
    1q54
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (254547311..254589596, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (244598285..244633835, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (265506752..265542452, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 8 Neighboring gene nucleophosmin/nucleoplasmin, 3 Neighboring gene potassium voltage-gated channel interacting protein 2 Neighboring gene armadillo-like helical domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in N-acetylglucosamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in N-acetylglucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carbohydrate derivative metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dATP metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycoprotein metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cardiac muscle adaptation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of D-glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of calcium ion transport into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell killing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of growth hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein-containing complex disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein deglycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein deglycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein O-GlcNAcase
    Names
    N-acetyl-beta-D-glucosaminidase
    N-acetyl-beta-glucosaminidase
    beta-N-acetylhexosaminidase
    beta-hexosaminidase
    bifunctional protein NCOAT
    meningioma expressed antigen 5 (hyaluronidase)
    meningioma-expressed antigen 5
    nuclear cytoplasmic O-GlcNAcase and acetyltransferase
    protein O-GlcNAcase-like
    NP_571979.1
    XP_017444197.1
    XP_063127739.1
    XP_063127766.1
    XP_063127795.1
    XP_063127835.1
    XP_063127855.1
    XP_063127887.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131904.2NP_571979.1  protein O-GlcNAcase

      See identical proteins and their annotated locations for NP_571979.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q8VIJ5
      UniProtKB/TrEMBL
      A0A8I6ALY4
      Related
      ENSRNOP00000112378.1, ENSRNOT00000156205.1
      Conserved Domains (1) summary
      pfam07555
      Location:62338
      NAGidase; beta-N-acetylglucosaminidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      254547311..254589596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588708.3XP_017444197.1  protein O-GlcNAcase isoform X4

      UniProtKB/TrEMBL
      A0A8I6AAH5, A0A8I6ALY4
      Related
      ENSRNOP00000088821.1, ENSRNOT00000109554.2
    2. XM_063271725.1XP_063127795.1  protein O-GlcNAcase isoform X3

      UniProtKB/TrEMBL
      A0A0H2UI10, A0A8I6ALY4
      Related
      ENSRNOP00000059568.3, ENSRNOT00000065172.5
    3. XM_063271669.1XP_063127739.1  protein O-GlcNAcase isoform X1

    4. XM_063271696.1XP_063127766.1  protein O-GlcNAcase isoform X2

    5. XM_063271765.1XP_063127835.1  protein O-GlcNAcase isoform X5

    6. XM_063271817.1XP_063127887.1  protein O-GlcNAcase isoform X7

    7. XM_063271785.1XP_063127855.1  protein O-GlcNAcase isoform X6

    RNA

    1. XR_010056626.1 RNA Sequence

    2. XR_005488864.2 RNA Sequence