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    Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 15467, updated on 6-Sep-2021

    Summary

    Official Symbol
    Eif2ak1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2 alpha kinase 1provided by MGI
    Primary source
    MGI:MGI:1353448
    See related
    Ensembl:ENSMUSG00000029613
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H; HCR; Hri
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 46.8), liver E14 (RPKM 43.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Eif2ak1 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143803530..143839535)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143817792..143902717)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (144632731..144663586)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 42 Neighboring gene predicted gene, 38737 Neighboring gene RIKEN cDNA D130017N08 gene Neighboring gene ankyrin repeat domain 61 Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 Neighboring gene PMS1 homolog2, mismatch repair system component Neighboring gene CCZ1 vacuolar protein trafficking and biogenesis associated Neighboring gene predicted gene, 24311

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118066

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in HRI-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within acute inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in integrated stress response signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of hemoglobin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein autophosphorylation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within protoporphyrinogen IX metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of eIF2 alpha phosphorylation by heme IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of hemoglobin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to iron ion starvation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 2-alpha kinase 1
    Names
    heme-controlled repressor
    heme-regulated eukaryotic initiation factor eIF-2-alpha kinase
    heme-regulated inhibitor
    hemin-sensitive initiation factor 2-alpha kinase
    NP_038585.2
    XP_017176174.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013557.2NP_038585.2  eukaryotic translation initiation factor 2-alpha kinase 1

      See identical proteins and their annotated locations for NP_038585.2

      Status: VALIDATED

      Source sequence(s)
      AK173160, BB625879, DV644671
      Consensus CDS
      CCDS84994.1
      UniProtKB/Swiss-Prot
      Q9Z2R9
      Related
      ENSMUSP00000098056.5, ENSMUST00000100487.6
      Conserved Domains (2) summary
      cd14049
      Location:160578
      STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase
      pfam00069
      Location:167580
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143803530..143839535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320685.3XP_017176174.1  eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:160507
      PKc_like; Protein Kinases, catalytic domain
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