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    Agfg1 ArfGAP with FG repeats 1 [ Mus musculus (house mouse) ]

    Gene ID: 15463, updated on 23-Jun-2021

    Summary

    Official Symbol
    Agfg1provided by MGI
    Official Full Name
    ArfGAP with FG repeats 1provided by MGI
    Primary source
    MGI:MGI:1333754
    See related
    Ensembl:ENSMUSG00000026159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hr; Hrb; RAB; Rip; C85612; AU045498; C130049H11Rik; D730048C23Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 19.1), liver E14.5 (RPKM 13.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Agfg1 in Genome Data Viewer
    Location:
    1; 1 C5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (82816738..82878722)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (82839017..82901001)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (82836058..82892850)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17764 Neighboring gene predicted gene, 34450 Neighboring gene potassium channel tetramerisation domain containing 3 pseudogene Neighboring gene solute carrier family 19, member 3 Neighboring gene nascent polypeptide-associated complex alpha polypeptide pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    arf-GAP domain and FG repeat-containing protein 1
    Names
    HIV-1 Rev binding protein
    HIV-1 Rev-binding protein homolog
    arf-GAP domain and FG repeats-containing protein 1
    nucleoporin-like protein RIP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310713.1NP_001297642.1  arf-GAP domain and FG repeat-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AC125444, AK048326, AK049400, CJ159641
      Consensus CDS
      CCDS78634.1
      UniProtKB/Swiss-Prot
      Q8K2K6
      Related
      ENSMUSP00000109071.3, ENSMUST00000113444.8
      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    2. NM_001347077.1NP_001334006.1  arf-GAP domain and FG repeat-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125444, AC138214
      Consensus CDS
      CCDS83564.1
      UniProtKB/TrEMBL
      A0A087WSR7
      Related
      ENSMUSP00000141157.2, ENSMUST00000190052.7
    3. NM_001368850.1NP_001355779.1  arf-GAP domain and FG repeat-containing protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AC125444, AC138214
      Consensus CDS
      CCDS87854.1
      Related
      ENSMUSP00000140785.2, ENSMUST00000186302.7
      Conserved Domains (3) summary
      PHA03247
      Location:418548
      PHA03247; large tegument protein UL36; Provisional
      COG5347
      Location:8268
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    4. NM_010472.3NP_034602.1  arf-GAP domain and FG repeat-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_034602.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC125444, AK048326, CJ159641
      Consensus CDS
      CCDS15100.1
      UniProtKB/Swiss-Prot
      Q8K2K6
      Related
      ENSMUSP00000140170.2, ENSMUST00000189220.7
      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      82816738..82878722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496430.4XP_006496493.1  arf-GAP domain and FG repeat-containing protein 1 isoform X1

      Conserved Domains (2) summary
      COG5347
      Location:8268
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    2. XM_006496432.4XP_006496495.1  arf-GAP domain and FG repeat-containing protein 1 isoform X3

      Conserved Domains (2) summary
      COG5347
      Location:8268
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    3. XM_006496439.4XP_006496502.1  arf-GAP domain and FG repeat-containing protein 1 isoform X10

      Conserved Domains (4) summary
      PRK12799
      Location:382523
      motB; flagellar motor protein MotB; Reviewed
      COG5347
      Location:8268
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
      pfam11179
      Location:159439
      DUF2967; Protein of unknown function (DUF2967)
    4. XM_006496431.4XP_006496494.1  arf-GAP domain and FG repeat-containing protein 1 isoform X2

      Conserved Domains (3) summary
      COG5347
      Location:8268
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      PRK12727
      Location:385528
      PRK12727; flagellar biosynthesis protein FlhF
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    5. XM_036161582.1XP_036017475.1  arf-GAP domain and FG repeat-containing protein 1 isoform X4

      Conserved Domains (3) summary
      COG5347
      Location:8268
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      PRK12727
      Location:385540
      PRK12727; flagellar biosynthesis protein FlhF
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    6. XM_006496434.4XP_006496497.1  arf-GAP domain and FG repeat-containing protein 1 isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:417547
      PHA03247; large tegument protein UL36; Provisional
      COG5347
      Location:8268
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    7. XM_006496435.4XP_006496498.1  arf-GAP domain and FG repeat-containing protein 1 isoform X6

      Conserved Domains (3) summary
      COG5347
      Location:8268
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      PRK12727
      Location:385524
      PRK12727; flagellar biosynthesis protein FlhF
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    8. XM_006496438.4XP_006496501.1  arf-GAP domain and FG repeat-containing protein 1 isoform X9

      Conserved Domains (3) summary
      COG5347
      Location:8268
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
      pfam17823
      Location:381525
      DUF5585; Family of unknown function (DUF5585)
    9. XM_017316914.2XP_017172403.1  arf-GAP domain and FG repeat-containing protein 1 isoform X8

      Conserved Domains (2) summary
      pfam05109
      Location:355533
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    10. XM_006496440.4XP_006496503.1  arf-GAP domain and FG repeat-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A087WNV1
      Related
      ENSMUSP00000139503.2, ENSMUST00000187899.7
      Conserved Domains (2) summary
      PHA03247
      Location:378508
      PHA03247; large tegument protein UL36; Provisional
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    11. XM_030249680.1XP_030105540.1  arf-GAP domain and FG repeat-containing protein 1 isoform X13

      Conserved Domains (2) summary
      PHA03247
      Location:347515
      PHA03247; large tegument protein UL36; Provisional
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    12. XM_036161673.1XP_036017566.1  arf-GAP domain and FG repeat-containing protein 1 isoform X15

      Conserved Domains (1) summary
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    13. XM_030249597.1XP_030105457.1  arf-GAP domain and FG repeat-containing protein 1 isoform X7

      Conserved Domains (2) summary
      PRK12727
      Location:345488
      PRK12727; flagellar biosynthesis protein FlhF
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    14. XM_030249652.1XP_030105512.1  arf-GAP domain and FG repeat-containing protein 1 isoform X12

      Conserved Domains (2) summary
      PHA03247
      Location:377507
      PHA03247; large tegument protein UL36; Provisional
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    15. XM_036161661.1XP_036017554.1  arf-GAP domain and FG repeat-containing protein 1 isoform X14

      Conserved Domains (2) summary
      PRK12727
      Location:345484
      PRK12727; flagellar biosynthesis protein FlhF
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
    16. XM_036161682.1XP_036017575.1  arf-GAP domain and FG repeat-containing protein 1 isoform X16

      Conserved Domains (1) summary
      cd08857
      Location:13128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)

    RNA

    1. XR_001781825.2 RNA Sequence

    2. XR_003952111.1 RNA Sequence

    3. XR_001781822.2 RNA Sequence

    4. XR_003952114.1 RNA Sequence

    5. XR_004940179.1 RNA Sequence

    6. XR_373537.5 RNA Sequence

    7. XR_004940186.1 RNA Sequence

    8. XR_004940189.1 RNA Sequence

    9. XR_004940185.1 RNA Sequence

    10. XR_004940184.1 RNA Sequence

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