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    Hras Harvey rat sarcoma virus oncogene [ Mus musculus (house mouse) ]

    Gene ID: 15461, updated on 8-Jul-2024

    Summary

    Official Symbol
    Hrasprovided by MGI
    Official Full Name
    Harvey rat sarcoma virus oncogeneprovided by MGI
    Primary source
    MGI:MGI:96224
    See related
    Ensembl:ENSMUSG00000025499 AllianceGenome:MGI:96224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ras; H-ras; Hras1; Kras2; Ha-ras; Hras-1; c-H-ras; c-rasHa; c-Ha-ras; Harvey-ras
    Summary
    Enables GTP binding activity. Involved in Ras protein signal transduction. Acts upstream of or within several processes, including defense response to protozoan; intracellular signal transduction; and positive regulation of interferon-gamma production. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including central nervous system; early embryo; metanephros; sensory organ; and tooth. Used to study Costello syndrome; high grade glioma; and malignant astrocytoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 31.5), cortex adult (RPKM 31.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hras in Genome Data Viewer
    Location:
    7 F5; 7 86.48 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140770839..140773938, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141189934..141194019, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S9 pseudogene Neighboring gene predicted gene, 51459 Neighboring gene predicted gene, 22019 Neighboring gene STARR-positive B cell enhancer ABC_E9115 Neighboring gene STARR-positive B cell enhancer ABC_E11375 Neighboring gene leucine rich repeat containing 56 Neighboring gene lamin tail domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E1749 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (11)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-membrane adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-membrane adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERBB2-ERBB3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in Schwann cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T-helper 1 type immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular senescence IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular senescence IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within oncogene-induced cell senescence IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within small GTPase-mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of GTPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    GTPase HRas
    Names
    H-Ras-1
    H-ras 1 protein
    Harvey rat sarcoma virus oncogene 1
    c-Ha-ras p21 protein
    c-Ha-ras transgene
    p21ras
    transforming protein P21
    NP_001123915.1
    NP_001123916.1
    NP_001399407.1
    NP_001399408.1
    NP_001399409.1
    NP_001399410.1
    NP_032310.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130443.2NP_001123915.1  GTPase HRas isoform 1

      See identical proteins and their annotated locations for NP_001123915.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 3-7 all encode the same isoform (1).
      Source sequence(s)
      AC108908
      Consensus CDS
      CCDS22003.1
      UniProtKB/Swiss-Prot
      F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
      UniProtKB/TrEMBL
      Q9R0B8
      Related
      ENSMUSP00000095570.5, ENSMUST00000097957.11
      Conserved Domains (1) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    2. NM_001130444.2NP_001123916.1  GTPase HRas isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and includes an alternate exon in its 3' coding region, compared to variant 1. The resulting isoform (2) contains a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC108908
      Consensus CDS
      CCDS52439.1
      UniProtKB/TrEMBL
      A0A0G2JGP4
      Related
      ENSMUSP00000132110.2, ENSMUST00000168550.8
      Conserved Domains (2) summary
      cd04138
      Location:3150
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
      smart00010
      Location:16150
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    3. NM_001412478.1NP_001399407.1  GTPase HRas isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC108908
      UniProtKB/Swiss-Prot
      F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
      UniProtKB/TrEMBL
      Q9R0B8
    4. NM_001412479.1NP_001399408.1  GTPase HRas isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC108908
      UniProtKB/Swiss-Prot
      F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
      UniProtKB/TrEMBL
      Q9R0B8
    5. NM_001412480.1NP_001399409.1  GTPase HRas isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC108908
      UniProtKB/Swiss-Prot
      F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
      UniProtKB/TrEMBL
      Q9R0B8
    6. NM_001412481.1NP_001399410.1  GTPase HRas isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC108908
      UniProtKB/Swiss-Prot
      F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
      UniProtKB/TrEMBL
      Q9R0B8
    7. NM_008284.3NP_032310.2  GTPase HRas isoform 1

      See identical proteins and their annotated locations for NP_032310.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Isoform 1 is also known as p21. Variants 1 and 3-7 all encode the same isoform (1).
      Source sequence(s)
      AC108908
      Consensus CDS
      CCDS22003.1
      UniProtKB/Swiss-Prot
      F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
      UniProtKB/TrEMBL
      Q9R0B8
      Related
      ENSMUSP00000026572.5, ENSMUST00000026572.11
      Conserved Domains (1) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    RNA

    1. NR_178203.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108908
    2. NR_178204.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108908
    3. NR_178205.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108908
    4. NR_178206.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108908

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140770839..140773938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003946393.2 RNA Sequence

    2. XR_389952.4 RNA Sequence

      Related
      ENSMUST00000124971.2
    3. XR_004934018.1 RNA Sequence