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    Hprt hypoxanthine guanine phosphoribosyl transferase [ Mus musculus (house mouse) ]

    Gene ID: 15452, updated on 7-Sep-2021

    Summary

    Official Symbol
    Hprtprovided by MGI
    Official Full Name
    hypoxanthine guanine phosphoribosyl transferaseprovided by MGI
    Primary source
    MGI:MGI:96217
    See related
    Ensembl:ENSMUSG00000025630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hpr; HPGRT; Hprt1; C81579
    Summary
    The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in liver E14 (RPKM 48.8), cerebellum adult (RPKM 42.3) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Hprt in Genome Data Viewer
    Location:
    X A5; X 29.31 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (52076955..52110537)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (52988078..53021660)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (50341255..50374837)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2, pseudogene 13 Neighboring gene PHD finger protein 6 Neighboring gene microRNA 450-1 Neighboring gene microRNA 450b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC103149

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanine phosphoribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables guanine phosphoribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables hypoxanthine phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hypoxanthine phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hypoxanthine phosphoribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables hypoxanthine phosphoribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in AMP salvage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in GMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in GMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within GMP salvage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in GMP salvage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in GMP salvage ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in IMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in IMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in IMP salvage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
     
    acts_upstream_of_or_within adenine metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in adenine salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT acts_upstream_of_or_within grooming behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within grooming behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in guanine salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in guanine salvage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hypoxanthine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within hypoxanthine metabolic process IC
    Inferred by Curator
    more info
     
    acts_upstream_of_or_within hypoxanthine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hypoxanthine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hypoxanthine salvage ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
     
    acts_upstream_of_or_within lymphocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
     
    involved_in nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in purine nucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within purine ribonucleoside salvage IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within purine ribonucleoside salvage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in purine ribonucleoside salvage ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within striatum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hypoxanthine-guanine phosphoribosyltransferase
    Names
    HGPRT
    HGPRTase
    HPRT B
    hypoxanthine guanine phosphoribosyl transferase 1
    NP_038584.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013556.2NP_038584.2  hypoxanthine-guanine phosphoribosyltransferase

      See identical proteins and their annotated locations for NP_038584.2

      Status: REVIEWED

      Source sequence(s)
      AK002286, AK146626, BY285280
      Consensus CDS
      CCDS40972.1
      UniProtKB/Swiss-Prot
      P00493
      Related
      ENSMUSP00000026723.9, ENSMUST00000026723.9
      Conserved Domains (1) summary
      cl00309
      Location:6218
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      52076955..52110537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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