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    CYLD CYLD lysine 63 deubiquitinase [ Homo sapiens (human) ]

    Gene ID: 1540, updated on 5-May-2024

    Summary

    Official Symbol
    CYLDprovided by HGNC
    Official Full Name
    CYLD lysine 63 deubiquitinaseprovided by HGNC
    Primary source
    HGNC:HGNC:2584
    See related
    Ensembl:ENSG00000083799 MIM:605018; AllianceGenome:HGNC:2584
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2; FTDALS8
    Summary
    This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 13.0), lymph node (RPKM 10.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    16q12.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (50742086..50801935)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (56539727..56599616)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50775997..50835846)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10821 Neighboring gene sorting nexin 20 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10825 Neighboring gene Sharpr-MPRA regulatory region 14141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7490 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:50743936-50744141 Neighboring gene nucleotide binding oligomerization domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10826 Neighboring gene Sharpr-MPRA regulatory region 1297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10827 Neighboring gene CYLD antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10828 Neighboring gene microRNA 3181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7492 Neighboring gene CYLD antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50843053-50844052 Neighboring gene long intergenic non-protein coding RNA 2168 Neighboring gene VISTA enhancer hs162 Neighboring gene long intergenic non-protein coding RNA 2128 Neighboring gene RNA, 5S ribosomal pseudogene 426

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2021-02-10)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2021-02-10)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog
    Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    EBI GWAS Catalog
    Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of CYLD by siRNA enhances HIV-1 infection in a single-cycle assay in HEK 293T cells, and the CYLD catalytic mutant C698A fails to reduce HIV-1 infection in 293T cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 transcription increases upon CYLD knockdown in CD4+ T lymphocytes, leading to upregulation of HIV-1 Gag/p24 levels in cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • HSPC057, FLJ20180, FLJ31664, FLJ78684, KIAA0849

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables K63-linked deubiquitinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables K63-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables K63-linked deubiquitinase activity TAS
    Traceable Author Statement
    more info
     
    enables Met1-linked polyubiquitin deubiquitinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
     
    enables proline-rich region binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in homeostasis of number of cells IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in necroptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-18-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of p38MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of type I interferon production TAS
    Traceable Author Statement
    more info
     
    involved_in nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein linear deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of necroptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in ripoptosome assembly involved in necroptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ciliary tip ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase CYLD
    Names
    cylindromatosis (turban tumor syndrome)
    deubiquitinating enzyme CYLD
    probable ubiquitin carboxyl-terminal hydrolase CYLD
    ubiquitin specific peptidase like 2
    ubiquitin thioesterase CYLD
    ubiquitin thiolesterase CYLD
    ubiquitin-specific-processing protease CYLD
    NP_001035814.1
    NP_001035877.1
    NP_001365672.1
    NP_001365673.1
    NP_001365674.1
    NP_001365675.1
    NP_001365676.1
    NP_001365677.1
    NP_001365678.1
    NP_001365679.1
    NP_001365680.1
    NP_001365681.1
    NP_001365682.1
    NP_001365683.1
    NP_001365684.1
    NP_056062.1
    XP_047289612.1
    XP_047289614.1
    XP_047289615.1
    XP_047289616.1
    XP_047289617.1
    XP_047289618.1
    XP_047289619.1
    XP_047289620.1
    XP_054235669.1
    XP_054235670.1
    XP_054235671.1
    XP_054235672.1
    XP_054235673.1
    XP_054235674.1
    XP_054235675.1
    XP_054235676.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012061.1 RefSeqGene

      Range
      5001..64886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_491

    mRNA and Protein(s)

    1. NM_001042355.2NP_001035814.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

      See identical proteins and their annotated locations for NP_001035814.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks one exon in the 5' UTR and a second in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AJ250014, AK056226, AL050166, BI458962, BX642061, DA157717, DA785459, DA940312
      Consensus CDS
      CCDS42164.1
      UniProtKB/TrEMBL
      A8KAB0
      Related
      ENSP00000457576.1, ENST00000569418.5
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    2. NM_001042412.3NP_001035877.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

      See identical proteins and their annotated locations for NP_001035877.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' terminal exon, and lacks one exon in the 5' UTR and another in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC007728
      Consensus CDS
      CCDS42164.1
      UniProtKB/TrEMBL
      A8KAB0
      Related
      ENSP00000381574.2, ENST00000398568.6
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    3. NM_001378743.1NP_001365672.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC007728
      Consensus CDS
      CCDS45482.1
      UniProtKB/Swiss-Prot
      O94934, Q7L3N6, Q96EH0, Q9NQC7, Q9NZX9
      UniProtKB/TrEMBL
      A8KAB0
      Related
      ENSP00000392025.3, ENST00000427738.8
      Conserved Domains (3) summary
      smart01052
      Location:472540
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:593948
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307471
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    4. NM_001378744.1NP_001365673.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC007728
      Consensus CDS
      CCDS42164.1
      UniProtKB/TrEMBL
      A8KAB0
      Related
      ENSP00000454515.1, ENST00000564326.5
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    5. NM_001378745.1NP_001365674.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC007728
      Consensus CDS
      CCDS42164.1
      UniProtKB/TrEMBL
      A8KAB0
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    6. NM_001378746.1NP_001365675.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC007728
      Consensus CDS
      CCDS42164.1
      UniProtKB/TrEMBL
      A8KAB0
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    7. NM_001378747.1NP_001365676.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC007728
      Consensus CDS
      CCDS42164.1
      UniProtKB/TrEMBL
      A8KAB0
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    8. NM_001378748.1NP_001365677.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC007728
      Consensus CDS
      CCDS42164.1
      UniProtKB/TrEMBL
      A8KAB0
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    9. NM_001378749.1NP_001365678.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC007728
      Consensus CDS
      CCDS42164.1
      UniProtKB/TrEMBL
      A8KAB0
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    10. NM_001378750.1NP_001365679.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC007728
      Consensus CDS
      CCDS42164.1
      UniProtKB/TrEMBL
      A8KAB0
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    11. NM_001378751.1NP_001365680.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC007728
      UniProtKB/TrEMBL
      A8KAB0
      Conserved Domains (3) summary
      smart01052
      Location:459527
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:580935
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304458
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    12. NM_001378752.1NP_001365681.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC007728
      UniProtKB/TrEMBL
      A8KAB0
      Conserved Domains (3) summary
      smart01052
      Location:459527
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:580935
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304458
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    13. NM_001378753.1NP_001365682.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC007728
      UniProtKB/TrEMBL
      A8KAB0
      Related
      ENSP00000456488.2, ENST00000568704.2
      Conserved Domains (3) summary
      smart01052
      Location:459527
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:580935
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304458
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    14. NM_001378754.1NP_001365683.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC007728
      UniProtKB/TrEMBL
      B3KND1
      Conserved Domains (3) summary
      smart01052
      Location:247315
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:368723
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:82246
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    15. NM_001378755.1NP_001365684.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC007728
      UniProtKB/TrEMBL
      B3KND1
      Conserved Domains (3) summary
      smart01052
      Location:247315
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:368723
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:82246
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    16. NM_015247.3NP_056062.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 1

      See identical proteins and their annotated locations for NP_056062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC007728
      Consensus CDS
      CCDS45482.1
      UniProtKB/Swiss-Prot
      O94934, Q7L3N6, Q96EH0, Q9NQC7, Q9NZX9
      UniProtKB/TrEMBL
      A8KAB0
      Related
      ENSP00000308928.9, ENST00000311559.13
      Conserved Domains (3) summary
      smart01052
      Location:472540
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:593948
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307471
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    RNA

    1. NR_166071.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007728

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      50742086..50801935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433656.1XP_047289612.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    2. XM_047433661.1XP_047289617.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    3. XM_047433663.1XP_047289619.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

    4. XM_047433664.1XP_047289620.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

    5. XM_047433658.1XP_047289614.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    6. XM_047433662.1XP_047289618.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    7. XM_047433659.1XP_047289615.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    8. XM_047433660.1XP_047289616.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    RNA

    1. XR_007064858.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      56539727..56599616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379694.1XP_054235669.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    2. XM_054379698.1XP_054235673.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    3. XM_054379700.1XP_054235675.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

    4. XM_054379701.1XP_054235676.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

    5. XM_054379695.1XP_054235670.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    6. XM_054379699.1XP_054235674.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    7. XM_054379696.1XP_054235671.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    8. XM_054379697.1XP_054235672.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    RNA

    1. XR_008489063.1 RNA Sequence