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    Hnrnpab heterogeneous nuclear ribonucleoprotein A/B [ Mus musculus (house mouse) ]

    Gene ID: 15384, updated on 5-Sep-2021

    Summary

    Official Symbol
    Hnrnpabprovided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A/Bprovided by MGI
    Primary source
    MGI:MGI:1330294
    See related
    Ensembl:ENSMUSG00000020358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hn; CBF-; Cgbf; CBF-A; Cgbfa; Hnrpab; 3010025C11Rik
    Summary
    This gene encodes a protein with consensus RNA binding domains present in a number of other RNA binding proteins and a glycine-rich C-terminus. This gene overlaps in a tail-to-tail orientation the gene encoding alanine-glyoxylate aminotransferase 2-like 2. Some of the exons of this gene are interspersed with exons of alanine-glyoxylate aminotransferase 2-like 2. Two alternatively spliced transcript variants that encode distinct proteins have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary adult (RPKM 222.6), CNS E11.5 (RPKM 200.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Hnrnpab in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51490927..51497708, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51600100..51606881, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (51413602..51420383, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC049762 Neighboring gene CDC like kinase 4 Neighboring gene collagen, type XXIII, alpha 1 Neighboring gene 5-phosphohydroxy-L-lysine phospholyase Neighboring gene RIKEN cDNA D930048N14 gene Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene NHP2 ribonucleoprotein Neighboring gene NEDD4 binding protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein A/B
    Names
    CArG-binding factor-A
    S1 protein D2
    hnRNP A/B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048061.1NP_001041526.1  heterogeneous nuclear ribonucleoprotein A/B isoform 1

      See identical proteins and their annotated locations for NP_001041526.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AL645602, BQ445737, CA325334, CF751043, CJ166869
      Consensus CDS
      CCDS48787.1
      UniProtKB/TrEMBL
      Q20BD0
      Related
      ENSMUSP00000104731.4, ENSMUST00000109103.4
      Conserved Domains (3) summary
      cd12584
      Location:155234
      RRM2_hnRNPAB; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
      cd12757
      Location:76150
      RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
      pfam08143
      Location:175
      CBFNT; CBFNT (NUC161) domain
    2. NM_010448.3NP_034578.1  heterogeneous nuclear ribonucleoprotein A/B isoform 2

      See identical proteins and their annotated locations for NP_034578.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AK013384, CJ166869
      Consensus CDS
      CCDS24654.1
      UniProtKB/Swiss-Prot
      Q99020
      UniProtKB/TrEMBL
      Q544Z3
      Related
      ENSMUSP00000074238.4, ENSMUST00000074669.10
      Conserved Domains (3) summary
      cd12757
      Location:76150
      RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
      pfam08143
      Location:175
      CBFNT; CBFNT (NUC161) domain
      cl17169
      Location:155234
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      51490927..51497708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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