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    Hmox2 heme oxygenase 2 [ Mus musculus (house mouse) ]

    Gene ID: 15369, updated on 14-Sep-2021

    Summary

    Official Symbol
    Hmox2provided by MGI
    Official Full Name
    heme oxygenase 2provided by MGI
    Primary source
    MGI:MGI:109373
    See related
    Ensembl:ENSMUSG00000004070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HO; HO-; HO2; HO-2
    Expression
    Broad expression in testis adult (RPKM 136.2), cerebellum adult (RPKM 25.6) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Hmox2 in Genome Data Viewer
    Location:
    16 A1; 16 2.46 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4544225..4584606)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4726361..4766742)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (4726361..4766249)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene NmrA-like family domain containing 1 Neighboring gene cell death inducing Trp53 target 1 Neighboring gene RIKEN cDNA 4930562C15 gene Neighboring gene predicted gene, 36513 Neighboring gene UBA-like domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables heme oxygenase (decyclizing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables heme oxygenase (decyclizing) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in heme catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in heme oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heme oxygenase 2
    Names
    heme oxygenase (decycling) 2
    NP_001129538.1
    NP_001343979.1
    NP_001365928.1
    NP_034573.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136066.2NP_001129538.1  heme oxygenase 2 isoform 1

      See identical proteins and their annotated locations for NP_001129538.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK134536, BP769523, BY071995
      Consensus CDS
      CCDS27924.1
      UniProtKB/Swiss-Prot
      O70252
      UniProtKB/TrEMBL
      Q544R7
      Related
      ENSMUSP00000004172.9, ENSMUST00000004172.15
      Conserved Domains (1) summary
      pfam01126
      Location:30235
      Heme_oxygenase; Heme oxygenase
    2. NM_001357050.1NP_001343979.1  heme oxygenase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166903
      Conserved Domains (1) summary
      pfam01126
      Location:58263
      Heme_oxygenase; Heme oxygenase
    3. NM_001378999.1NP_001365928.1  heme oxygenase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166903
      Conserved Domains (1) summary
      pfam01126
      Location:49254
      Heme_oxygenase; Heme oxygenase
    4. NM_010443.2NP_034573.2  heme oxygenase 2 isoform 1

      See identical proteins and their annotated locations for NP_034573.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to transcript variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK134536, BP769523, CA465845
      Consensus CDS
      CCDS27924.1
      UniProtKB/Swiss-Prot
      O70252
      UniProtKB/TrEMBL
      Q544R7
      Related
      ENSMUSP00000112397.2, ENSMUST00000120232.8
      Conserved Domains (1) summary
      pfam01126
      Location:30235
      Heme_oxygenase; Heme oxygenase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      4544225..4584606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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