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    TTC23L tetratricopeptide repeat domain 23 like [ Homo sapiens (human) ]

    Gene ID: 153657, updated on 17-Jun-2024

    Summary

    Official Symbol
    TTC23Lprovided by HGNC
    Official Full Name
    tetratricopeptide repeat domain 23 likeprovided by HGNC
    Primary source
    HGNC:HGNC:26355
    See related
    Ensembl:ENSG00000205838 MIM:616344; AllianceGenome:HGNC:26355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MC25-1
    Summary
    Predicted to be located in cytoplasm; microtubule cytoskeleton; and midbody. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 3.3), adrenal (RPKM 0.3) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TTC23L in Genome Data Viewer
    Location:
    5p13.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (34839164..34925682)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (35086287..35172714)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (34839269..34925787)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15966 Neighboring gene RAI14 divergent transcript Neighboring gene retinoic acid induced 14 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:34700297-34700798 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:34700799-34701298 Neighboring gene uncharacterized LOC124900960 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:34721500-34722000 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:34722001-34722501 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:34735806-34736306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:34736307-34736807 Neighboring gene NANOG hESC enhancer GRCh37_chr5:34736814-34737353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22465 Neighboring gene MPRA-validated peak5222 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22466 Neighboring gene uncharacterized LOC124900959 Neighboring gene TTC23L antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:34866693-34867892 Neighboring gene ribosomal protein L21 pseudogene 54 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr5:34915193-34915798 and GRCh37_chr5:34915799-34916404 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:34922818-34924017 Neighboring gene uncharacterized LOC124900961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:34930148-34930793 Neighboring gene RAD1 checkpoint DNA exonuclease Neighboring gene biogenesis of ribosomes BRX1 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:34955801-34955974 Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22470 Neighboring gene alanine--glyoxylate aminotransferase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of tetratricopeptide repeat domain 23-like (TTC23L) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25439

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in response to endoplasmic reticulum stress NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 23-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317949.2NP_001304878.1  tetratricopeptide repeat protein 23-like isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC026801, JN799997
      UniProtKB/TrEMBL
      A0A1W2PP54
      Conserved Domains (1) summary
      pfam13424
      Location:262341
      TPR_12; Tetratricopeptide repeat
    2. NM_001386169.1NP_001373098.1  tetratricopeptide repeat protein 23-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC026801
      UniProtKB/TrEMBL
      A0A1W2PP54
      Related
      ENSP00000491000.1, ENST00000638320.2
    3. NM_001386170.1NP_001373099.1  tetratricopeptide repeat protein 23-like isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC026801
      UniProtKB/TrEMBL
      A0A1W2PP54
    4. NM_001386171.1NP_001373100.1  tetratricopeptide repeat protein 23-like isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC026801
      UniProtKB/TrEMBL
      A0A1W2PP54
    5. NM_001386172.1NP_001373101.1  tetratricopeptide repeat protein 23-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC026801
      Consensus CDS
      CCDS54840.1
      UniProtKB/Swiss-Prot
      G8IJH6, Q6PF05, Q6RGS4, Q8N7R3, Q96LJ2
      UniProtKB/TrEMBL
      A0A1W2PP54
      Related
      ENSP00000513788.1, ENST00000698543.1
    6. NM_144725.4NP_653326.3  tetratricopeptide repeat protein 23-like isoform 2

      See identical proteins and their annotated locations for NP_653326.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start site, and contains a shorter 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC026801, AK058168, BC057775, BX088767
      Consensus CDS
      CCDS54840.1
      UniProtKB/Swiss-Prot
      G8IJH6, Q6PF05, Q6RGS4, Q8N7R3, Q96LJ2
      UniProtKB/TrEMBL
      A0A1W2PP54
      Related
      ENSP00000422188.1, ENST00000505624.6
      Conserved Domains (1) summary
      pfam13424
      Location:253332
      TPR_12; Tetratricopeptide repeat

    RNA

    1. NR_169874.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC026801
    2. NR_169875.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC026801
    3. NR_169876.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC026801

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      34839164..34925682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416824.1XP_047272780.1  tetratricopeptide repeat protein 23-like isoform X1

      UniProtKB/TrEMBL
      A0A1W2PP54, A0A3B3IS63
    2. XM_017009120.3XP_016864609.1  tetratricopeptide repeat protein 23-like isoform X1

      UniProtKB/TrEMBL
      A0A1W2PP54, A0A3B3IS63
      Conserved Domains (1) summary
      pfam13424
      Location:253332
      TPR_12; Tetratricopeptide repeat
    3. XM_011513984.4XP_011512286.1  tetratricopeptide repeat protein 23-like isoform X1

      UniProtKB/TrEMBL
      A0A1W2PP54, A0A3B3IS63
      Related
      ENSP00000497109.1, ENST00000514080.2
      Conserved Domains (1) summary
      pfam13424
      Location:253332
      TPR_12; Tetratricopeptide repeat
    4. XM_011513985.3XP_011512287.1  tetratricopeptide repeat protein 23-like isoform X3

      UniProtKB/TrEMBL
      A0A1W2PP54
      Conserved Domains (1) summary
      pfam13424
      Location:253332
      TPR_12; Tetratricopeptide repeat
    5. XM_017009123.3XP_016864612.1  tetratricopeptide repeat protein 23-like isoform X4

      UniProtKB/TrEMBL
      A0A1W2PP54
    6. XM_047416826.1XP_047272782.1  tetratricopeptide repeat protein 23-like isoform X6

    7. XM_011513987.4XP_011512289.1  tetratricopeptide repeat protein 23-like isoform X6

      Related
      ENSP00000484792.1, ENST00000610313.1
    8. XM_017009121.3XP_016864610.1  tetratricopeptide repeat protein 23-like isoform X1

      UniProtKB/TrEMBL
      A0A1W2PP54, A0A3B3IS63
      Conserved Domains (1) summary
      pfam13424
      Location:253332
      TPR_12; Tetratricopeptide repeat
    9. XM_017009119.3XP_016864608.1  tetratricopeptide repeat protein 23-like isoform X2

      UniProtKB/TrEMBL
      A0A1W2PP54
    10. XM_017009124.3XP_016864613.1  tetratricopeptide repeat protein 23-like isoform X5

    11. XM_017009122.3XP_016864611.1  tetratricopeptide repeat protein 23-like isoform X1

      UniProtKB/TrEMBL
      A0A1W2PP54, A0A3B3IS63
      Conserved Domains (1) summary
      pfam13424
      Location:253332
      TPR_12; Tetratricopeptide repeat
    12. XM_017009126.3XP_016864615.1  tetratricopeptide repeat protein 23-like isoform X8

    13. XM_047416825.1XP_047272781.1  tetratricopeptide repeat protein 23-like isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      35086287..35172714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351826.1XP_054207801.1  tetratricopeptide repeat protein 23-like isoform X1

      UniProtKB/TrEMBL
      A0A1W2PP54
    2. XM_054351823.1XP_054207798.1  tetratricopeptide repeat protein 23-like isoform X1

      UniProtKB/TrEMBL
      A0A1W2PP54
    3. XM_054351824.1XP_054207799.1  tetratricopeptide repeat protein 23-like isoform X1

      UniProtKB/TrEMBL
      A0A1W2PP54
    4. XM_054351829.1XP_054207804.1  tetratricopeptide repeat protein 23-like isoform X3

      UniProtKB/TrEMBL
      A0A1W2PP54
    5. XM_054351830.1XP_054207805.1  tetratricopeptide repeat protein 23-like isoform X4

      UniProtKB/TrEMBL
      A0A1W2PP54
    6. XM_054351834.1XP_054207809.1  tetratricopeptide repeat protein 23-like isoform X6

    7. XM_054351832.1XP_054207807.1  tetratricopeptide repeat protein 23-like isoform X6

    8. XM_054351827.1XP_054207802.1  tetratricopeptide repeat protein 23-like isoform X1

      UniProtKB/TrEMBL
      A0A1W2PP54
    9. XM_054351825.1XP_054207800.1  tetratricopeptide repeat protein 23-like isoform X2

      UniProtKB/TrEMBL
      A0A1W2PP54
    10. XM_054351831.1XP_054207806.1  tetratricopeptide repeat protein 23-like isoform X5

    11. XM_054351833.1XP_054207808.1  tetratricopeptide repeat protein 23-like isoform X7

    12. XM_054351835.1XP_054207810.1  tetratricopeptide repeat protein 23-like isoform X8

    13. XM_054351828.1XP_054207803.1  tetratricopeptide repeat protein 23-like isoform X1

      UniProtKB/TrEMBL
      A0A1W2PP54