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    Hmgn2 high mobility group nucleosomal binding domain 2 [ Mus musculus (house mouse) ]

    Gene ID: 15331, updated on 26-Sep-2022

    Summary

    Official Symbol
    Hmgn2provided by MGI
    Official Full Name
    high mobility group nucleosomal binding domain 2provided by MGI
    Primary source
    MGI:MGI:96136
    See related
    Ensembl:ENSMUSG00000003038 AllianceGenome:MGI:96136
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hmg17; HMG-17
    Summary
    Predicted to enable chromatin binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of development, heterochronic. Located in nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; heart; and lung. Used to study Axenfeld-Rieger syndrome type 1. Orthologous to human HMGN2 (high mobility group nucleosomal binding domain 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 375.6), limb E14.5 (RPKM 204.2) and 12 other tissues See more
    Orthologs
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    Genomic context

    See Hmgn2 in Genome Data Viewer
    Location:
    4 D2.3; 4 66.47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133692050..133695302, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133964739..133967991, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase polypeptide 1 Neighboring gene predicted gene 12977 Neighboring gene predicted gene, 22523 Neighboring gene dehydrodolichyl diphosphate synthase Neighboring gene lin-28 homolog A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102472, MGC103137, MGC103384, MGC118420

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in female germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    non-histone chromosomal protein HMG-17
    Names
    high mobility group nucleosome-binding domain-containing protein 2
    high mobility group protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016957.3NP_058653.1  non-histone chromosomal protein HMG-17

      See identical proteins and their annotated locations for NP_058653.1

      Status: VALIDATED

      Source sequence(s)
      AK146999, BC090836, CJ053675
      Consensus CDS
      CCDS18759.1
      UniProtKB/Swiss-Prot
      P09602
      UniProtKB/TrEMBL
      A0A6P5PGA5, Q5BL14
      Related
      ENSMUSP00000099613.5, ENSMUST00000102553.11
      Conserved Domains (1) summary
      pfam01101
      Location:188
      HMG14_17; HMG14 and HMG17

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      133692050..133695302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)