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    Hmgb1 high mobility group box 1 [ Mus musculus (house mouse) ]

    Gene ID: 15289, updated on 19-Mar-2019

    Summary

    Official Symbol
    Hmgb1provided by MGI
    Official Full Name
    high mobility group box 1provided by MGI
    Primary source
    MGI:MGI:96113
    See related
    Ensembl:ENSMUSG00000066551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p30; Hmg1; HMG-1; SBP-1
    Summary
    This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in CNS E11.5 (RPKM 22.0), liver E14 (RPKM 17.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See Hmgb1 in Genome Data Viewer
    Location:
    5 G3; 5 89.18 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (149046702..149053057, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (149858803..149864613, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene 15411 Neighboring gene RIKEN cDNA 5930430L01 gene Neighboring gene predicted gene 15408 Neighboring gene predicted gene, 30078 Neighboring gene predicted gene, 38752

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC103168, MGC103169, MGC117896, MGC117897

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding, bending IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    bent DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    crossed form four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    open form four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylserine binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA geometric change ISO
    Inferred from Sequence Orthology
    more info
     
    DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to interleukin-7 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endothelial cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    induction of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    macrophage activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myeloid dendritic cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plasmacytoid dendritic cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of NIK/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of NIK/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-alpha production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-alpha secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-1 beta secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interleukin-1 beta secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-1 secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interleukin-6 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mesenchymal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of monocyte chemotactic protein-1 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of toll-like receptor 2 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of T cell mediated immune response to tumor cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of tolerance induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to glucocorticoid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    high mobility group protein B1
    Names
    amphoterin
    high mobility group protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313894.1NP_001300823.1  high mobility group protein B1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC158782, AK037928, AK084841, AK144428, CJ187465
      Consensus CDS
      CCDS19883.1
      UniProtKB/Swiss-Prot
      P63158
      UniProtKB/TrEMBL
      Q58EV5
      Related
      ENSMUSP00000106131.1, ENSMUST00000093196.10
      Conserved Domains (2) summary
      pfam00505
      Location:95162
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:778
      HMG_box_2; HMG-box domain
    2. NM_010439.4NP_034569.1  high mobility group protein B1

      See identical proteins and their annotated locations for NP_034569.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein
      Source sequence(s)
      AC158782, AK084841, AK144428, CJ050650
      Consensus CDS
      CCDS19883.1
      UniProtKB/Swiss-Prot
      P63158
      UniProtKB/TrEMBL
      Q58EV5
      Related
      ENSMUSP00000082682.6, ENSMUST00000085546.12
      Conserved Domains (2) summary
      pfam00505
      Location:95162
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:778
      HMG_box_2; HMG-box domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      149046702..149053057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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