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    Hipk3 homeodomain interacting protein kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 15259, updated on 31-Jan-2019

    Summary

    Official Symbol
    Hipk3provided by MGI
    Official Full Name
    homeodomain interacting protein kinase 3provided by MGI
    Primary source
    MGI:MGI:1314882
    See related
    Ensembl:ENSMUSG00000027177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PKY; DYRK6; FIST3; mir-1902
    Expression
    Ubiquitous expression in heart adult (RPKM 35.4), testis adult (RPKM 25.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hipk3 in Genome Data Viewer
    Location:
    2; 2 E2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (104426481..104494489, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (104266638..104334646, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D430041D05 gene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 35606 Neighboring gene microRNA 1902 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene SWIM type zinc finger 7 associated protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    homeodomain-interacting protein kinase 3
    Names
    ANPK
    FIST
    HCMV-interacting protein
    androgen receptor-interacting nuclear protein kinase
    fas-interacting serine/threonine-protein kinase
    nbak3
    nuclear body-associated kinase 3
    NP_001139296.1
    NP_034564.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145824.1NP_001139296.1  homeodomain-interacting protein kinase 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is one aa shorter compared to isoform 1.
      Source sequence(s)
      AK140130, AL844591, BC131664
      UniProtKB/TrEMBL
      A2RRJ7, Q3UST3
      Conserved Domains (2) summary
      smart00220
      Location:197525
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:196525
      PKc_like; Protein Kinases, catalytic domain
    2. NM_010434.2NP_034564.2  homeodomain-interacting protein kinase 3 isoform 1

      See identical proteins and their annotated locations for NP_034564.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK140130, AL844591, AL954370
      Consensus CDS
      CCDS16489.1
      UniProtKB/Swiss-Prot
      Q9ERH7
      UniProtKB/TrEMBL
      Q3UST3
      Related
      ENSMUSP00000028600.7, ENSMUST00000028600.13
      Conserved Domains (2) summary
      smart00220
      Location:197525
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:196525
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      104426481..104494489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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