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    Hint1 histidine triad nucleotide binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 15254, updated on 4-Nov-2018

    Summary

    Official Symbol
    Hint1provided by MGI
    Official Full Name
    histidine triad nucleotide binding protein 1provided by MGI
    Primary source
    MGI:MGI:1321133
    See related
    Ensembl:ENSMUSG00000020267 Vega:OTTMUSG00000005678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hint; Ipk1; PKCI-1; PRKCNH1; AA673479
    Expression
    Ubiquitous expression in kidney adult (RPKM 346.0), duodenum adult (RPKM 283.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hint1 in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (54866438..54870496)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (54679940..54683998)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene LYR motif containing 7 Neighboring gene ATPase family, AAA domain containing 1 pseudogene Neighboring gene predicted gene, 31490 Neighboring gene glutathione peroxidase 3 Neighboring gene TNFAIP3 interacting protein 1 Neighboring gene 40S ribosomal protein S11-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    purine ribonucleotide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histidine triad nucleotide-binding protein 1
    Names
    PKC inhibitor/ interacting protein
    adenosine 5'-monophosphoramidase
    protein kinase C inhibitor 1
    protein kinase C-interacting protein 1
    NP_032274.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008248.3NP_032274.1  histidine triad nucleotide-binding protein 1

      See identical proteins and their annotated locations for NP_032274.1

      Status: VALIDATED

      Source sequence(s)
      BC070415, BE995722, BY261801
      Consensus CDS
      CCDS24702.1
      UniProtKB/Swiss-Prot
      P70349
      Related
      ENSMUSP00000020504.5, OTTMUSP00000005856, ENSMUST00000020504.5
      Conserved Domains (1) summary
      cd01276
      Location:16118
      PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      54866438..54870496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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