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    Hgs HGF-regulated tyrosine kinase substrate [ Mus musculus (house mouse) ]

    Gene ID: 15239, updated on 5-Aug-2018

    Summary

    Official Symbol
    Hgsprovided by MGI
    Official Full Name
    HGF-regulated tyrosine kinase substrateprovided by MGI
    Primary source
    MGI:MGI:104681
    See related
    Ensembl:ENSMUSG00000025793 Ensembl:ENSMUSG00000116045 Vega:OTTMUSG00000004240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tn; Hgr; Hrs; ZFYVE8
    Expression
    Ubiquitous expression in testis adult (RPKM 102.6), adrenal adult (RPKM 78.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hgs in Genome Data Viewer
    Location:
    11 E2; 11 84.16 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (120467635..120483984)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (120328949..120345298)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene oxidoreductase like domain containing 1 Neighboring gene coiled-coil domain containing 137 Neighboring gene ADP-ribosylation factor-like 16 Neighboring gene mitochondrial ribosomal protein L12 Neighboring gene solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    teetering
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Transgenic (1) 
    • Targeted (6)  1 citation

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    membrane invagination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein targeting to lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    ESCRT-0 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hepatocyte growth factor-regulated tyrosine kinase substrate

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159328.1NP_001152800.1  hepatocyte growth factor-regulated tyrosine kinase substrate isoform 1

      See identical proteins and their annotated locations for NP_001152800.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK046299, AK145031, BY315543, CJ294093
      Consensus CDS
      CCDS49005.1
      UniProtKB/Swiss-Prot
      Q99LI8
      UniProtKB/TrEMBL
      Q3UMA3
      Related
      ENSMUSP00000026900.7, ENSMUST00000026900.13
      Conserved Domains (6) summary
      cd03569
      Location:4145
      VHS_Hrs_Vps27p; VHS domain family, Hrs and Vps27p subfamily; composed of Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and its yeast homolog Vps27p (vacuolar protein sorting). The VHS domain, an essential part of Hrs/Vps27p, has a superhelical ...
      cd15720
      Location:159219
      FYVE_Hrs; FYVE domain found in hepatocyte growth factor (HGF)-regulated tyrosine kinase substrate (Hrs) and similar proteins
      pfam07223
      Location:518736
      DUF1421; Protein of unknown function (DUF1421)
      pfam12210
      Location:406500
      Hrs_helical; Hepatocyte growth factor-regulated tyrosine kinase substrate
      cd16269
      Location:530541
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:485559
      GBP_C; Guanylate-binding protein, C-terminal domain
    2. NM_008244.3NP_032270.3  hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2

      See identical proteins and their annotated locations for NP_032270.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. This difference results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK046299, AK145031, BY315543, CJ294093
      UniProtKB/Swiss-Prot
      Q99LI8
      UniProtKB/TrEMBL
      Q3UMA3
      Related
      ENSMUSP00000101811.1, OTTMUSP00000004646, ENSMUST00000106205.7, OTTMUST00000009585
      Conserved Domains (6) summary
      cd03569
      Location:4145
      VHS_Hrs_Vps27p; VHS domain family, Hrs and Vps27p subfamily; composed of Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and its yeast homolog Vps27p (vacuolar protein sorting). The VHS domain, an essential part of Hrs/Vps27p, has a superhelical ...
      cd15720
      Location:159219
      FYVE_Hrs; FYVE domain found in hepatocyte growth factor (HGF)-regulated tyrosine kinase substrate (Hrs) and similar proteins
      pfam07223
      Location:517735
      DUF1421; Protein of unknown function (DUF1421)
      pfam12210
      Location:405499
      Hrs_helical; Hepatocyte growth factor-regulated tyrosine kinase substrate
      cd16269
      Location:529540
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:484558
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      120467635..120483984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532270.2XP_006532333.2  hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1

      Conserved Domains (7) summary
      cd03569
      Location:4145
      VHS_Hrs_Vps27p; VHS domain family, Hrs and Vps27p subfamily; composed of Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and its yeast homolog Vps27p (vacuolar protein sorting). The VHS domain, an essential part of Hrs/Vps27p, has a superhelical ...
      cd15720
      Location:159219
      FYVE_Hrs; FYVE domain found in hepatocyte growth factor (HGF)-regulated tyrosine kinase substrate (Hrs) and similar proteins
      pfam05466
      Location:220397
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam07223
      Location:525769
      DUF1421; Protein of unknown function (DUF1421)
      pfam12210
      Location:413507
      Hrs_helical; Hepatocyte growth factor-regulated tyrosine kinase substrate
      cd16269
      Location:537548
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:492566
      GBP_C; Guanylate-binding protein, C-terminal domain
    2. XM_006532274.2XP_006532337.2  hepatocyte growth factor-regulated tyrosine kinase substrate isoform X5

      Conserved Domains (7) summary
      cd03569
      Location:4145
      VHS_Hrs_Vps27p; VHS domain family, Hrs and Vps27p subfamily; composed of Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and its yeast homolog Vps27p (vacuolar protein sorting). The VHS domain, an essential part of Hrs/Vps27p, has a superhelical ...
      cd15720
      Location:159219
      FYVE_Hrs; FYVE domain found in hepatocyte growth factor (HGF)-regulated tyrosine kinase substrate (Hrs) and similar proteins
      pfam05466
      Location:220397
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam07223
      Location:525743
      DUF1421; Protein of unknown function (DUF1421)
      pfam12210
      Location:413507
      Hrs_helical; Hepatocyte growth factor-regulated tyrosine kinase substrate
      cd16269
      Location:537548
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:492566
      GBP_C; Guanylate-binding protein, C-terminal domain
    3. XM_006532271.2XP_006532334.2  hepatocyte growth factor-regulated tyrosine kinase substrate isoform X2

      Conserved Domains (6) summary
      cd03569
      Location:4145
      VHS_Hrs_Vps27p; VHS domain family, Hrs and Vps27p subfamily; composed of Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and its yeast homolog Vps27p (vacuolar protein sorting). The VHS domain, an essential part of Hrs/Vps27p, has a superhelical ...
      cd15720
      Location:159219
      FYVE_Hrs; FYVE domain found in hepatocyte growth factor (HGF)-regulated tyrosine kinase substrate (Hrs) and similar proteins
      pfam07223
      Location:524768
      DUF1421; Protein of unknown function (DUF1421)
      pfam12210
      Location:412506
      Hrs_helical; Hepatocyte growth factor-regulated tyrosine kinase substrate
      cd16269
      Location:536547
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:491565
      GBP_C; Guanylate-binding protein, C-terminal domain
    4. XM_006532272.2XP_006532335.2  hepatocyte growth factor-regulated tyrosine kinase substrate isoform X3

      Conserved Domains (7) summary
      cd03569
      Location:4145
      VHS_Hrs_Vps27p; VHS domain family, Hrs and Vps27p subfamily; composed of Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and its yeast homolog Vps27p (vacuolar protein sorting). The VHS domain, an essential part of Hrs/Vps27p, has a superhelical ...
      cd15720
      Location:159219
      FYVE_Hrs; FYVE domain found in hepatocyte growth factor (HGF)-regulated tyrosine kinase substrate (Hrs) and similar proteins
      pfam05466
      Location:220382
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam07223
      Location:518762
      DUF1421; Protein of unknown function (DUF1421)
      pfam12210
      Location:406500
      Hrs_helical; Hepatocyte growth factor-regulated tyrosine kinase substrate
      cd16269
      Location:530541
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:485559
      GBP_C; Guanylate-binding protein, C-terminal domain
    5. XM_006532273.2XP_006532336.2  hepatocyte growth factor-regulated tyrosine kinase substrate isoform X4

      Conserved Domains (6) summary
      cd03569
      Location:4145
      VHS_Hrs_Vps27p; VHS domain family, Hrs and Vps27p subfamily; composed of Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and its yeast homolog Vps27p (vacuolar protein sorting). The VHS domain, an essential part of Hrs/Vps27p, has a superhelical ...
      cd15720
      Location:159219
      FYVE_Hrs; FYVE domain found in hepatocyte growth factor (HGF)-regulated tyrosine kinase substrate (Hrs) and similar proteins
      pfam07223
      Location:517761
      DUF1421; Protein of unknown function (DUF1421)
      pfam12210
      Location:405499
      Hrs_helical; Hepatocyte growth factor-regulated tyrosine kinase substrate
      cd16269
      Location:529540
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:484558
      GBP_C; Guanylate-binding protein, C-terminal domain
    6. XM_017314293.1XP_017169782.1  hepatocyte growth factor-regulated tyrosine kinase substrate isoform X6

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