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    Herc2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]

    Gene ID: 15204, updated on 23-Jun-2021

    Summary

    Official Symbol
    Herc2provided by MGI
    Official Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase 2provided by MGI
    Primary source
    MGI:MGI:103234
    See related
    Ensembl:ENSMUSG00000030451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    r; rjs; jdf2; D15F32S1; D15F32S1h; D7H15F32S; D7H15F37S; mKIAA0393; D7H15F32S1; D7H15F37S1
    Expression
    Ubiquitous expression in CNS E18 (RPKM 12.1), cortex adult (RPKM 11.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Herc2 in Genome Data Viewer
    Location:
    7 B5; 7 33.42 cM
    Exon count:
    93
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (55699872..55884373)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (56050124..56231800)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (63305525..63487170)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S12-like 1 Neighboring gene non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human) Neighboring gene predicted gene, 34121 Neighboring gene predicted gene, 51510 Neighboring gene solute carrier family 1 (neutral amino acid transporter), member 5 pseudogene Neighboring gene oculocutaneous albinism II Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3 Neighboring gene predicted gene, 17984

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Gene trapped (1) 
    • Chemically induced (ENU) (11)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0393

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase HERC2
    Names
    HECT domain and RCC1-like domain-containing protein 2
    HECT-type E3 ubiquitin transferase HERC2
    hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2
    probable E3 ubiquitin-protein ligase HERC2
    NP_001347009.1
    NP_034548.2
    XP_006540700.1
    XP_006540702.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360080.1NP_001347009.1  E3 ubiquitin-protein ligase HERC2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC102121, AC102150
      Consensus CDS
      CCDS21318.1
      Related
      ENSMUSP00000131573.2, ENSMUST00000164095.3
      Conserved Domains (9) summary
      cd08664
      Location:27662911
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:29573323
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:44234794
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:27072751
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:24612508
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:12121283
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam06701
      Location:18711930
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:25552632
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam18346
      Location:26402697
      SH3_15; Mind bomb SH3 repeat domain
    2. NM_010418.2NP_034548.2  E3 ubiquitin-protein ligase HERC2

      See identical proteins and their annotated locations for NP_034548.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AF061529, AF071173, AK148361, BP754028, BY241058
      Consensus CDS
      CCDS21318.1
      UniProtKB/Swiss-Prot
      Q4U2R1
      Related
      ENSMUSP00000075579.7, ENSMUST00000076226.13
      Conserved Domains (9) summary
      cd08664
      Location:27662911
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:29573323
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:44234794
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:27072751
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:24612508
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:12121283
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam06701
      Location:18711930
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:25552632
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam18346
      Location:26402697
      SH3_15; Mind bomb SH3 repeat domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      55699872..55884373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540639.3XP_006540702.1  E3 ubiquitin-protein ligase HERC2 isoform X2

      UniProtKB/Swiss-Prot
      Q4U2R1
      Related
      ENSMUSP00000145997.2, ENSMUST00000205303.2
      Conserved Domains (9) summary
      cd08664
      Location:27662911
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:29573323
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:43874758
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:27072751
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:24612508
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:12121283
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam06701
      Location:18711930
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:25552632
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam18346
      Location:26402697
      SH3_15; Mind bomb SH3 repeat domain
    2. XM_006540637.4XP_006540700.1  E3 ubiquitin-protein ligase HERC2 isoform X1

      See identical proteins and their annotated locations for XP_006540700.1

      UniProtKB/Swiss-Prot
      Q4U2R1
      Conserved Domains (9) summary
      cd08664
      Location:27662911
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:29573323
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:44234794
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:27072751
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:24612508
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:12121283
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam06701
      Location:18711930
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:25552632
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam18346
      Location:26402697
      SH3_15; Mind bomb SH3 repeat domain
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