U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ROPN1B rhophilin associated tail protein 1B [ Homo sapiens (human) ]

    Gene ID: 152015, updated on 23-Nov-2023

    Summary

    Official Symbol
    ROPN1Bprovided by HGNC
    Official Full Name
    rhophilin associated tail protein 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:31927
    See related
    Ensembl:ENSG00000114547 AllianceGenome:HGNC:31927
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables protein heterodimerization activity. Predicted to be involved in several processes, including flagellated sperm motility; protein localization to cilium; and sperm capacitation. Located in cytoplasm and motile cilium. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 113.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ROPN1B in Genome Data Viewer
    Location:
    3q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (125969178..125983454)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (128701549..128715814)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (125688021..125702297)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:125635188-125635778 Neighboring gene family with sequence similarity 86, member A pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125650034-125650534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125650535-125651035 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125655344-125655844 Neighboring gene ALG1 like 1, pseudogene Neighboring gene FBRSL1 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:125736296-125736478 Neighboring gene solute carrier family 41 member 3 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:125740258-125741040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125744116-125744616 Neighboring gene uncharacterized LOC124909425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125777675-125778174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14673 Neighboring gene ALDH1L1 and SLC41A3 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor complex adaptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in acrosome reaction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell-cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cilium organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoskeleton-dependent cytokinesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in flagellated sperm motility TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein localization to cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sperm capacitation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ropporin-1B
    Names
    AKAP-binding sperm protein ropporin
    rhophilin-associated protein 1B
    ropporin, rhophilin associated protein 1B
    testis tissue sperm-binding protein Li 83P

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012337.3NP_001012337.1  ropporin-1B

      See identical proteins and their annotated locations for NP_001012337.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF231410, HY006578
      Consensus CDS
      CCDS33841.1
      UniProtKB/Swiss-Prot
      D3DNA6, Q96BM7, Q9BZX4
      UniProtKB/TrEMBL
      A0A140VKG6
      Related
      ENSP00000251776.4, ENST00000251776.8
      Conserved Domains (1) summary
      cl02594
      Location:1244
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
    2. NM_001308313.2NP_001295242.1  ropporin-1B

      See identical proteins and their annotated locations for NP_001295242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC141849, DC397187
      Consensus CDS
      CCDS33841.1
      UniProtKB/Swiss-Prot
      D3DNA6, Q96BM7, Q9BZX4
      UniProtKB/TrEMBL
      A0A140VKG6
      Related
      ENSP00000426271.1, ENST00000514116.6
      Conserved Domains (1) summary
      cl02594
      Location:1244
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      125969178..125983454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713513.4XP_006713576.1  ropporin-1B isoform X1

      See identical proteins and their annotated locations for XP_006713576.1

      UniProtKB/Swiss-Prot
      D3DNA6, Q96BM7, Q9BZX4
      UniProtKB/TrEMBL
      A0A140VKG6
      Conserved Domains (1) summary
      cl02594
      Location:1244
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
    2. XM_005247138.4XP_005247195.1  ropporin-1B isoform X2

      See identical proteins and their annotated locations for XP_005247195.1

      UniProtKB/Swiss-Prot
      Q9BZX4
      Related
      ENSP00000421662.1, ENST00000505382.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      128701549..128715814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345358.1XP_054201333.1  ropporin-1B isoform X1

      UniProtKB/Swiss-Prot
      D3DNA6, Q96BM7, Q9BZX4
      UniProtKB/TrEMBL
      A0A140VKG6
    2. XM_054345359.1XP_054201334.1  ropporin-1B isoform X2