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    Hdgf heparin binding growth factor [ Mus musculus (house mouse) ]

    Gene ID: 15191, updated on 3-Dec-2024

    Summary

    Official Symbol
    Hdgfprovided by MGI
    Official Full Name
    heparin binding growth factorprovided by MGI
    Primary source
    MGI:MGI:1194494
    See related
    Ensembl:ENSMUSG00000004897 AllianceGenome:MGI:1194494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D3Ertd299e
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; cytoskeletal protein binding activity; and growth factor activity. Acts upstream of or within cellular response to interleukin-7 and negative regulation of neuron apoptotic process. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; liver; sensory organ; and telencephalon ventricular layer. Orthologous to human HDGF (heparin binding growth factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 92.7), CNS E11.5 (RPKM 90.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hdgf in Genome Data Viewer
    Location:
    3 F1; 3 38.78 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87813844..87823439)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87906090..87916132)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:87650795-87651072 Neighboring gene SH2 domain containing 2A Neighboring gene papillary renal cell carcinoma (translocation-associated) Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:87689595-87689778 Neighboring gene STARR-seq mESC enhancer starr_08164 Neighboring gene STARR-seq mESC enhancer starr_08165 Neighboring gene STARR-positive B cell enhancer ABC_E10190 Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene methyltransferase like 25B Neighboring gene STARR-positive B cell enhancer ABC_E9556 Neighboring gene interferon stimulated exonuclease gene 20-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hepatoma-derived growth factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331051.2NP_001317980.1  hepatoma-derived growth factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158233
    2. NM_001331052.2NP_001317981.1  hepatoma-derived growth factor isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158233
      UniProtKB/TrEMBL
      E0CXA0
      Related
      ENSMUSP00000124803.2, ENSMUST00000159492.8
      Conserved Domains (1) summary
      cl02554
      Location:760
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
    3. NM_001410032.1NP_001396961.1  hepatoma-derived growth factor isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158233
      UniProtKB/TrEMBL
      E0CXA0
    4. NM_001410033.1NP_001396962.1  hepatoma-derived growth factor isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC158233
      UniProtKB/TrEMBL
      E0CXA0
    5. NM_001410034.1NP_001396963.1  hepatoma-derived growth factor isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC158233
    6. NM_001410035.1NP_001396964.1  hepatoma-derived growth factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158233
    7. NM_001410036.1NP_001396965.1  hepatoma-derived growth factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158233
    8. NM_001410037.1NP_001396966.1  hepatoma-derived growth factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158233
    9. NM_001410038.1NP_001396967.1  hepatoma-derived growth factor isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158233
      UniProtKB/TrEMBL
      E0CXA0
    10. NM_001410039.1NP_001396968.1  hepatoma-derived growth factor isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158233
      UniProtKB/TrEMBL
      E0CXA0
    11. NM_001410040.1NP_001396969.1  hepatoma-derived growth factor isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158233
      UniProtKB/TrEMBL
      E0CXA0
    12. NM_001410041.1NP_001396970.1  hepatoma-derived growth factor isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC158233
      UniProtKB/TrEMBL
      E0CXA0
    13. NM_001410042.1NP_001396971.1  hepatoma-derived growth factor isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC158233
    14. NM_008231.5NP_032257.3  hepatoma-derived growth factor isoform 1

      See identical proteins and their annotated locations for NP_032257.3

      Status: VALIDATED

      Source sequence(s)
      AC158233
      Consensus CDS
      CCDS17457.1
      UniProtKB/Swiss-Prot
      P51859, Q8BPG7, Q9CYA4, Q9JK87
      UniProtKB/TrEMBL
      E0CXA0
      Related
      ENSMUSP00000005017.9, ENSMUST00000005017.15
      Conserved Domains (1) summary
      cd05834
      Location:892
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87813844..87823439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)