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    Hdgf heparin binding growth factor [ Mus musculus (house mouse) ]

    Gene ID: 15191, updated on 19-Feb-2019

    Summary

    Official Symbol
    Hdgfprovided by MGI
    Official Full Name
    heparin binding growth factorprovided by MGI
    Primary source
    MGI:MGI:1194494
    See related
    Ensembl:ENSMUSG00000004897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI118077; D3Ertd299e
    Expression
    Ubiquitous expression in liver E14 (RPKM 92.7), CNS E11.5 (RPKM 90.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hdgf in Genome Data Viewer
    Location:
    3 F1; 3 38.78 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (87906321..87916132)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (87710243..87720054)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 2A Neighboring gene papillary renal cell carcinoma (translocation-associated) Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene ribosomal RNA adenine dimethylase domain containing 1 Neighboring gene interferon stimulated exonuclease gene 20-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to interleukin-7 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional repressor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hepatoma-derived growth factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331051.1NP_001317980.1  hepatoma-derived growth factor isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA267834, AC158233, AK008393, BQ748111, BU054421, BY074214, CA752078
    2. NM_001331052.1NP_001317981.1  hepatoma-derived growth factor isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AA267834, AK008393, BQ748111, BU054421, BY074214, BY100429, CA752078
    3. NM_008231.4NP_032257.3  hepatoma-derived growth factor isoform 1

      See identical proteins and their annotated locations for NP_032257.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA267834, AK017863, AK029475, CJ173614
      Consensus CDS
      CCDS17457.1
      UniProtKB/Swiss-Prot
      P51859
      Related
      ENSMUSP00000005017.8, ENSMUST00000005017.14
      Conserved Domains (1) summary
      cd05834
      Location:892
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      87906321..87916132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501027.3XP_006501090.1  hepatoma-derived growth factor isoform X1

    2. XM_006501028.3XP_006501091.1  hepatoma-derived growth factor isoform X2

      Related
      ENSMUSP00000124803.1, ENSMUST00000159492.7
      Conserved Domains (1) summary
      cl02554
      Location:760
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
    3. XM_006501029.3XP_006501092.1  hepatoma-derived growth factor isoform X2

      See identical proteins and their annotated locations for XP_006501092.1

      Conserved Domains (1) summary
      cl02554
      Location:760
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
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